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Titolo:
ELEVATED PLASMA-LEVELS OF INTERLEUKIN-1 RECEPTOR ANTAGONIST AND INTERLEUKIN-20 IN PATIENTS WITH ACUTE MYOCARDIAL-INFARCTION
Autore:
SHIBATA M; ENDO S; INADA K; KURIKI S; HARADA M; TAKINO T; SATO N; ARAKAWA N; SUZUKI T; AOKI H; SUZUKI T; HIRAMORI K;
Indirizzi:
IWATE MED UNIV,DEPT INTERNAL MED 2,19-1 UCHIMARU MORIOKA IWATE 020 JAPAN IWATE MED UNIV,CRIT CARE EMERGENCY CTR MORIOKA IWATE 020 JAPAN IWATE MED UNIV,DEPT BACTERIOL MORIOKA IWATE 020 JAPAN
Titolo Testata:
Journal of interferon & cytokine research
fascicolo: 3, volume: 17, anno: 1997,
pagine: 145 - 150
SICI:
1079-9907(1997)17:3<145:EPOIRA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; ESCHERICHIA-COLI; SHOCK; ENDOTOXEMIA; INHIBITOR; RABBITS; INJURY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
M. Shibata et al., "ELEVATED PLASMA-LEVELS OF INTERLEUKIN-1 RECEPTOR ANTAGONIST AND INTERLEUKIN-20 IN PATIENTS WITH ACUTE MYOCARDIAL-INFARCTION", Journal of interferon & cytokine research, 17(3), 1997, pp. 145-150

Abstract

The study was undertaken to measure plasma interleukin-1 (IL-1) receptor antagonist and IL-10 concentrations in patients with acute myocardial infarction and to analyze their relationship to the hemodynamics, severity, and prognosis of myocardial infarction in its acute stages. We attempted to define the kinetics of IL-1 receptor antagonist and IL-10 in patients with acute myocardial infarction (n = 34, age 42-91 years, mean 68 years). Plasma IL-1 receptor antagonist and IL-10 levels were measured by enzyme-linked immunosorbent assay. Patients in group A (n = 17) had uncomplicated acute myocardial infarction (Killip classI). Patients in group B (n = 17) had severe acute myocardial infarction (Killip class II, III, or IV). Peak II-1 receptor antagonist and IL-10 levels in group B were significantly higher (p < 0.05) than those of group A. In group B, the peak IL-1 receptor antagonist levels were significantly correlated with white blood cell counts (r = 0.63, p = 0.006), pulmonary capillary wedge pressure (r = 0.78, p = 0.0002), and cardiac index (r = -0.51, p = 0.04). Peak IL-10 levels were significantly correlated with white blood cell counts (r = 0.60, p 0.01), the pulmonary wedge pressure (r = 0.73, p = 0.0008), and cardiac index (r = -0.50, p = 0.04). Moreover, a significant correlation was found between the peak IL-1 receptor antagonist and IL-10 levels (r = 0.91,p < 0.0001). The peak IL-1 receptor antagonist levels in nonsurvivors (n = 13) were significantly higher (p < 0.01) than those in survivors (n = 21). The plasma IL-1 receptor antagonist and LL-10 levels were closely correlated with the severity of hemodynamics in acute myocardial infarction and with the clinical status of patients with severe acute myocardial infarction. Results suggest that plasma IL-1 receptor antagonist and IL-10 can serve as prognostic indicators in cases of sever acute myocardial infarction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 19:31:42