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Titolo:
SEROTONIN 5-HT2A RECEPTOR-BINDING IN PLATELETS FROM HEALTHY-SUBJECTS AS STUDIED BY [H-3] LYSERGIC-ACID DIETHYLAMIDE ([H-3]-LSD) - INTRA-INDIVIDUAL AND INTERINDIVIDUAL VARIABILITY
Autore:
SPIGSET O; MJORNDAL T;
Indirizzi:
NORRLAND UNIV HOSP,DIV CLIN PHARMACOL S-90185 UMEA SWEDEN
Titolo Testata:
Neuropsychopharmacology
fascicolo: 4, volume: 16, anno: 1997,
pagine: 285 - 293
SICI:
0893-133X(1997)16:4<285:S5RIPF>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 LSD BINDING; BLOOD-PLATELETS; FRONTAL-CORTEX; H-3-IMIPRAMINE BINDING; PROTEIN DETERMINATION; NEUROLEPTIC TREATMENT; DEPRESSED-PATIENTS; AUTISTIC DISORDER; SUICIDAL-BEHAVIOR; SITES;
Keywords:
RECEPTORS, SEROTONIN; BLOOD PLATELETS; LYSERGIC ACID DIETHYLAMIDE; BLOOD PRESSURE; CONTRACEPTIVES, ORAL; SEASONS; BODY WEIGHT; BODY MASS INDEX; MENSTRUAL CYCLE; CYTOCHROME P-450;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
O. Spigset e T. Mjorndal, "SEROTONIN 5-HT2A RECEPTOR-BINDING IN PLATELETS FROM HEALTHY-SUBJECTS AS STUDIED BY [H-3] LYSERGIC-ACID DIETHYLAMIDE ([H-3]-LSD) - INTRA-INDIVIDUAL AND INTERINDIVIDUAL VARIABILITY", Neuropsychopharmacology, 16(4), 1997, pp. 285-293

Abstract

In studies on platelet 5-HT2A receptor binding in patients with neuropsychiatric disorders, there has been a marked variability and a considerable overlap of values between patients and controls. The causes ofthe large variability in 5-HT2A receptor parameters is still unsettled. In the present study, we have quantified the intra- and interindividual variability of platelet 5-HT2A receptor binding in 112 healthy subjects and explored factors that may influence 5-HT2A receptor binding, using [H-3]-lysergic acid diethylamide as radioligand. Age, gender, blood pressure, and metabolic capacity of the liver enzymes CYP2D6 andCYP2C19 did not influence B-max and K-d values. Body weight and body mass index (BMI) showed a negative correlation with K-d (p = .04 and .03, respectively), but not with B-max. B-max was significantly lower in the light half of the year than in the dark half of the year (p = .001), and K-d was significantly lower in the fall than in the summer and winter (p < .001). In females, there was a significant increase in B-max from week 1 to week 2 of the menstrual cycle (p = .03). Females taking contraceptive pills had significantly higher K-d than drug-free females in weeks 1 and 4 of the menstrual cycle (p = .04). This study shows that a number of factors should be taken into account when usingplatelet 5-HT2A receptor binding in studies of neuropsychiatric disorders. (C) 1997 American College of Neuropsychopharmacology.

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Documento generato il 25/01/20 alle ore 15:42:42