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Titolo:
COMPARATIVE EFFECTS OF 2 ONCE-DAILY REGIMENS OF POLICOSANOL IN PATIENTS WITH TYPE-II HYPERCHOLESTEROLEMIA
Autore:
CASTANO G; MAS R; FERNANDEZ JC; ILLNAIT J;
Indirizzi:
NATL CTR SCI RES,CTR MED SURG RES,POB 6880 HAVANA CUBA NATL CTR SCI RES,CTR MED SURG RES HAVANA CUBA NATL CTR SCI RES,CTR NAT PROD HAVANA CUBA
Titolo Testata:
Current therapeutic research
fascicolo: 3, volume: 58, anno: 1997,
pagine: 154 - 162
SICI:
0011-393X(1997)58:3<154:CEO2OR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-HEART-DISEASE; SPRAGUE-DAWLEY RATS; DENSITY LIPOPROTEIN; LIPID PROFILE; CHOLESTEROL; PREVENTION; TOXICITY; SAFETY; PLASMA; MEN;
Keywords:
POLICOSANOL; TYPE II HYPERCHOLESTEROLEMIA; DYSLIPIDEMIA; LIPID-LOWERING DRUG; CHOLESTEROL-LOWERING DRUG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
G. Castano et al., "COMPARATIVE EFFECTS OF 2 ONCE-DAILY REGIMENS OF POLICOSANOL IN PATIENTS WITH TYPE-II HYPERCHOLESTEROLEMIA", Current therapeutic research, 58(3), 1997, pp. 154-162

Abstract

This randomized, double-masked, placebo-controlled study compares theeffects of two different dosage schedules of policosanol administeredat 10 mg/d-two 5-mg tablets versus one 10-mg tablet taken once a day with the evening meal for 10 weeks, After 4 weeks on a step one cholesterol-lowering diet, 60 patients with type II hypercholesterolemia were randomly assigned to receive either two policosanol 5-mg tablets, one policosanol 10-mg tablet and one matched placebo tablet, or two placebo tablets, Both. regimens were similarly effective, Two 5-mg tabletsof policosanol significantly reduced total cholesterol (14.1%), low-density lipoprotein cholesterol (LDL-C) (21.1%), and the ratios of total cholesterol to high-density lipoprotein cholesterol (HDL-C) (22.8%) and LDL-C to HDL-C (27.9%), One 10-mg tablet of policosanol also significantly decreased total cholesterol (14.6%), LDL-C (23.2%), and the ratios of total cholesterol to HDL-C (29.5%) and LDL-C to HDL-C (35.8%), HDL-C levels were significantly raised in both treated groups (17.9%and 28.9%, respectively). Triglycerides did not significantly change in any group, Differences between treated groups were not significant,The placebo group did not show significant changes on lipid profile variables, Both policosanol schedules were well tolerated, No drug-related clinical or blood biochemistry disturbances were produced, Two patients withdrew from the study-one taking placebo and the other receiving two 5-mg tablets of policosanol, The patient on placebo withdrew because of an adverse experience (pruritus); no other adverse experiences were reported during the study, These results demonstrate that policosanol administered once daily with the evening meal as a 10-mg tabletis equivalent to taking two 5-mg tablets at the same time.

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Documento generato il 30/10/20 alle ore 09:08:31