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Titolo:
ACETYLCHOLINE AND CAROTID-BODY EXCITATION DURING HYPOXIA IN THE CAT
Autore:
FITZGERALD RS; SHIRAHATA M;
Indirizzi:
JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT ENVIRONM HLTH SCI,615 N WOLFE ST BALTIMORE MD 21205 JOHNS HOPKINS MED INST,DEPT ENVIRONM HLTH SCI,DIV PHYSIOL BALTIMORE MD 21205 JOHNS HOPKINS MED INST,DEPT MED,DIV PHYSIOL BALTIMORE MD 21205 JOHNS HOPKINS MED INST,DEPT PHYSIOL,DIV PHYSIOL BALTIMORE MD 21205 JOHNS HOPKINS MED INST,DEPT ANESTHESIOL CRIT CARE MED,DIV PHYSIOL BALTIMORE MD 21205
Titolo Testata:
Journal of applied physiology
fascicolo: 4, volume: 76, anno: 1994,
pagine: 1566 - 1574
SICI:
8750-7587(1994)76:4<1566:AACEDH>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTANCE-P; CHEMORECEPTOR RESPONSE; GANGLION; CURRENTS; ATROPINE; NEURONS; RABBIT; CELLS; DRUGS; DOGS;
Keywords:
CHOLINERGIC HYPOTHESIS; MECAMYLAMINE; ATROPINE; ALPHA-BUNGAROTOXIN; SUBSTANCE P;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
R.S. Fitzgerald e M. Shirahata, "ACETYLCHOLINE AND CAROTID-BODY EXCITATION DURING HYPOXIA IN THE CAT", Journal of applied physiology, 76(4), 1994, pp. 1566-1574

Abstract

The purpose of this study was to test the hypothesis that acetylcholine (ACh) is an excitatory neurotransmitter during the hypoxic stimulation of the carotid body. Cats were anesthetized, paralyzed, and artificially ventilated. The common carotid artery was fitted with a loop containing a stopcock for selectively perfusing the carotid body. Neuralactivity was recorded from the whole carotid sinus nerve. After the cats had been ventilated on 10% O-2 for 3 min with the carotid body being normally perfused with its own hypoxic arterial blood, the stopcockwas turned, and either equally hypoxic Krebs-Ringer bicarbonate solution (KRB) containing alpha-bungarotoxin, mecamylamine, and atropine orhypoxic blocker-free KRB perfused the carotid body for 2 min. The stopcock was returned to its original position, allowing blocker-free hypoxic blood to perfuse the carotid body once again. With this protocol we found 1) the cholinergic blockers reduced the carotid body responseto hypoxic KRB in a dose-dependent manner; 2) carotid baroreceptor activity was not reduced by the blockers, suggesting that the action of the blockers was not nonspecific (whereas lidocaine rapidly reduced both chemoreceptor and baroreceptor activity); 3) inclusion of the blockers in perfused hypoxic blood also reduced neural output from the carotid body; and 4) the blockers reduced the carotid body's neural response to hypoxic KRB containing substance P (20 mu g/100 ml), suggesting that substance P may be linked to ACh in the carotid body. We concludethat these data provide good evidence supportive of an excitatory role for ACh in carotid body hypoxic excitation.

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Documento generato il 02/12/20 alle ore 18:05:50