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Titolo:
THE INFLUENCE OF EXPERIMENTAL HYPERTHYROIDISM ON RESPONSIVENESS IN RABBIT AORTIC SMOOTH-MUSCLE
Autore:
UTKAN T; YUSUF S; ZAFER UN; KEMAL YM;
Indirizzi:
UNIV KOCAELI,FAC MED,DEPT PHARMACOL & TOXICOL TR-41900 DERINCE KOCAELI TURKEY UNIV CUMHURIYET,FAC MED,DEPT PHARMACOL TR-58140 SIVAS TURKEY UNIV KOCAELI,FAC MED,DEPT GEN SURG TR-41900 DERINCE KOCAELI TURKEY
Titolo Testata:
Environmental toxicology and pharmacology
fascicolo: 1, volume: 3, anno: 1997,
pagine: 7 - 11
SICI:
1382-6689(1997)3:1<7:TIOEHO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADRENERGIC-RECEPTOR NUMBER; THYROID-HORMONE REGULATION; RAT-HEART; RESPONSES; SUBTYPES; DRUGS;
Keywords:
HYPERTHYROIDISM; VASCULAR SMOOTH MUSCLE; NORADRENALINE; SEROTONIN; RABBIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
T. Utkan et al., "THE INFLUENCE OF EXPERIMENTAL HYPERTHYROIDISM ON RESPONSIVENESS IN RABBIT AORTIC SMOOTH-MUSCLE", Environmental toxicology and pharmacology, 3(1), 1997, pp. 7-11

Abstract

This study investigated the responsiveness of hyperthyroid and control (euthyroid) rabbit aortic rings to vasoconstrictor agents. There wasno significant difference between the responsiveness of hyperthyroid and control tissues to KCl. Maximum responses (E(m)) to noradrenaline and serotonin were reduced in hyperthyroid rabbit aortic rings compared to those euthyroid rings. The sensitivity (i.e., EC(50)) of hyperthyroid aortic rings to noradrenaline and serotonin compared to euthyroidcontrols was unchanged. The K-b value of prazosin against 10(-6) M noradrenaline-induced contractions in eu- and hyperthyroid states was 1.97 +/- 0.59 . 10(-9) M and 1.92 +/- 0.79 . 10(-9) M, respectively. TheK-b value of methisergide against 10(-6) M serotonin-induced contractions in eu- and hyperthyroid states was 1.46 +/- 0.80 . 10(-9) M and 1.10 +/- 0.16 . 10(-9) M, respectively. These data indicate that vascular reactivity is altered in experimental hyperthyroidism and this alteration, if any, do not occur at the receptor level. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:08:07