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Titolo:
QUANTIFICATION OF NEURORECEPTORS IN THE LIVING HUMAN BRAIN .4. EFFECTOF AGING AND ELEVATIONS OF D-2-LIKE RECEPTORS IN SCHIZOPHRENIA AND BIPOLAR ILLNESS
Autore:
WONG DF; PEARLSON GD; TUNE LE; YOUNG LT; MELTZER CC; DANNALS RF; RAVERT HT; REITH J; KUHAR MJ; GJEDDE A;
Indirizzi:
JOHNS HOPKINS MED INST,JHOC RES WING,ROOM 3245,601 N CAROLINE ST BALTIMORE MD 21287 AARHUS UNIV HOSP,PET CTR DK-8000 AARHUS DENMARK BISPEBJERG HOSP,DEPT NEUROL DK-2400 COPENHAGEN DENMARK MCGILL UNIV,DEPT NEUROL & NEUROSURG MONTREAL PQ CANADA NIDA,ADDICT RES CTR,NEUROSCI BRANCH,DEPT RADIOL & RADIOL SCI,DIV NUCLMED BALTIMORE MD 21224 NIDA,ADDICT RES CTR,NEUROSCI BRANCH,DEPT ENVIRONM HLTH SCI,DIV RADIATHLTH SCI BALTIMORE MD 21224 NIDA,ADDICT RES CTR,NEUROSCI BRANCH,DEPT PSYCHIAT BALTIMORE MD 21224 NIDA,ADDICT RES CTR,NEUROSCI BRANCH,DEPT NEUROSCI BALTIMORE MD 21224
Titolo Testata:
Journal of cerebral blood flow and metabolism
fascicolo: 3, volume: 17, anno: 1997,
pagine: 331 - 342
SICI:
0271-678X(1997)17:3<331:QONITL>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; D2 DOPAMINE-RECEPTORS; C-11 N-METHYLSPIPERONE; BINDING; D-2; DENSITY; DISORDER; SITES; PET;
Keywords:
POSITRON EMISSION TOMOGRAPHY; DOPAMINE RECEPTORS; SCHIZOPHRENIA; BIPOLAR ILLNESS; PSYCHOSIS; RECEPTOR QUANTIFICATION; DOPAMINE; D-4 DOPAMINE RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
D.F. Wong et al., "QUANTIFICATION OF NEURORECEPTORS IN THE LIVING HUMAN BRAIN .4. EFFECTOF AGING AND ELEVATIONS OF D-2-LIKE RECEPTORS IN SCHIZOPHRENIA AND BIPOLAR ILLNESS", Journal of cerebral blood flow and metabolism, 17(3), 1997, pp. 331-342

Abstract

In a previous study of 10 drug-naive schizophrenic patients, the density of D-2 dopamine receptors was found to be elevated in the caudate nucleus. The study raised questions about the influence of the age of the patients, the relationship of receptor density to psychosis, and the accuracy of the method used to obtain this evidence. Using positronemission tomography and constrained analysis of the brain uptake of the radioligand N-[C-11]methylspiperone ([C-11]NMSP), we tested four questions: Were the assumptions underlying the quantitation valid? Is there an age decline of the density of D-2-like dopamine receptors in drug-naive schizophrenia and bipolar illness? If so, is it different from that observed in normal aging? Are D-2-like dopamine receptors elevated at any age in either drug-naive schizophrenic or psychotic bipolarillness patients? NMSP and haloperidol partition volumes and plasma protein fractions were not significantly different among patient groupsand normal volunteers. The model-derived assay of radioligand metabolites in plasma was confirmed by high-performance liquid chromatographyin the patient groups. Dp-like dopamine receptors declined with age, and the slope did not differ significantly between the schizophrenic patients, bipolar affective illness patients, and normal controls. Taking the effect of age into account, increases in D-2 dopamine receptor density were found in seven psychotic patients with bipolar affective illness compared with seven nonpsychotic patients and 24 control subjects as well as in 22 drug-naive schizophrenic patients compared with the 24 control subjects.

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Documento generato il 27/01/20 alle ore 13:50:12