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Titolo:
HYPERCAPNIA REVERSIBLY SUPPRESSES LOW-FREQUENCY FLUCTUATIONS IN THE HUMAN MOTOR CORTEX DURING REST USING ECHO-PLANAR MRI
Autore:
BISWAL B; HUDETZ AG; YETKIN FZ; HAUGHTON VM; HYDE JS;
Indirizzi:
MED COLL WISCONSIN,BIOPHYS RES INST,8701 WATERTOWN PLANK RD,POB 26509MILWAUKEE WI 53226 MED COLL WISCONSIN,BIOPHYS RES INST MILWAUKEE WI 53226 MED COLL WISCONSIN,DEPT ANESTHESIOL MILWAUKEE WI 53226 MED COLL WISCONSIN,DEPT RADIOL MILWAUKEE WI 53226
Titolo Testata:
Journal of cerebral blood flow and metabolism
fascicolo: 3, volume: 17, anno: 1997,
pagine: 301 - 308
SICI:
0271-678X(1997)17:3<301:HRSLFI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; HUMAN BRAIN; FUNCTIONAL CONNECTIVITY; ELECTRICAL-STIMULATION; OXIDATIVE-METABOLISM; DATA SETS; VASODILATION; MOVEMENTS; INCREASE; FIELDS;
Keywords:
MAGNETIC RESONANCE; ECHO-PLANAR IMAGING; HUMAN CORTEX; HYPERCAPNIA; LOW FREQUENCY FLUCTUATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
B. Biswal et al., "HYPERCAPNIA REVERSIBLY SUPPRESSES LOW-FREQUENCY FLUCTUATIONS IN THE HUMAN MOTOR CORTEX DURING REST USING ECHO-PLANAR MRI", Journal of cerebral blood flow and metabolism, 17(3), 1997, pp. 301-308

Abstract

Using magnetic resonance (MR) echo-planar imaging (EPI), we recently demonstrated the presence of low-frequency fluctuations (<0.1 Hz) in MR signal intensity from the resting human brain that have a high degree of temporal correlation (p<10(-3)) within and across associated regions of the sensorimotor cortex. These fluctuations in MR signal intensity are believed to arise from fluctuations in capillary blood flow and oxygenation. A substantial overlap between the activation map generated by bilateral finger tapping and temporally-correlated voxels from the sensorimotor cortex obtained during rest was observed. In the workreported here, we investigated whether respiratory hypercapnia, whichis known to suspend spontaneous oscillations in regional cerebral blood flow, influences these low-frequency fluctuations. The magnitude oflow frequency fluctuations was reversibly diminished during hypercapnia, resulting in a substantial decrease of the temporal correlation both within and across contralateral hemispheres of the sensorimotor cortex, After the breathing mixture was returned to ambient air, the magnitude and spatial extent of the temporal correlation of low-frequency fluctuations returned to normal. Results of this study support the hypothesis that low-frequency physiological fluctuations observed by MR in the human cortex and spontaneous flow oscillations observed in earlystudies by laser-Doppler flowmetry (LDF) in the cortex of the rat areidentical and are secondary to fluctuations in neuronal activity.

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Documento generato il 04/04/20 alle ore 02:45:53