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Titolo:
CLASTOGENIC ACTIVITY IN THE PLASMA OF SCLERODERMA PATIENTS - A BIOMARKER OF OXIDATIVE STRESS
Autore:
EMERIT I; FILIPE P; MEUNIER P; AUCLAIR C; FREITAS J; DEROUSSENT A; GOUYETTE A; FERNANDES A;
Indirizzi:
15 RUE ECOLE MED F-75006 PARIS FRANCE UNIV PARIS 06,INST BIOMED CORDELIERS,FREE RAD RES GRP PARIS FRANCE CNRS PARIS FRANCE UNIV LISBON,HOSP SANTA MARIA,DEPT DERMATOL P-1699 LISBON PORTUGAL INST GUSTAVE ROUSSY VILLEJUIF FRANCE CNRS,DEPT PHARMACOTOXICOL & PHARMACOGENET VILLEJUIF FRANCE UNIV LISBON,CTR METAB & ENDOCRINOL P-1699 LISBON PORTUGAL
Titolo Testata:
Dermatology
fascicolo: 2, volume: 194, anno: 1997,
pagine: 140 - 146
SICI:
1018-8665(1997)194:2<140:CAITPO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM ADENOSINE-DEAMINASE; SYSTEMIC-SCLEROSIS; CHROMOSOMAL BREAKAGE; XANTHINE-OXIDASE; DNA; HYPOXANTHINE; GENERATION; DISORDERS; RESIDUES;
Keywords:
SCLERODERMA; CHROMOSOMAL BREAKAGE; CLASTOGENIC FACTORS; INOSINE TRIPHOSPHATE; ADENOSINE DEAMINASE; OXIDATIVE STRESS; SUPEROXIDE DISMUTASE; ANTIOXIDANTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
I. Emerit et al., "CLASTOGENIC ACTIVITY IN THE PLASMA OF SCLERODERMA PATIENTS - A BIOMARKER OF OXIDATIVE STRESS", Dermatology, 194(2), 1997, pp. 140-146

Abstract

Background: Scleroderma patients exhibit increased chromosomal instability due to circulating clastogenic plasma factors (CP). Formation and action mechanisms of CF are mediated by superoxide, in addition, previous work detected inosine triphosphate (ITP) in the plasma of 2 patients, and the enzyme adenosine deaminase (ADA) was found to be increased, Objective: To study correlations between CF, ITP and ADA levels, CF and disease activity, as well as other biomarkers of oxidative stress, Methods: Clastogenic activity was, evaluated by means of cytogenetic methods in 48 patients and 55 healthy subjects. ITP was detected by mass spectrometry and electrospray ionisation, ADA was measured with acolorimetric assay and malondialdehyde using the Yagi method, Results: Clastogenic activity was significantly increased in patients' plasmacompared to controls, In 10 patients CE ITP and ADA were studied simultaneously, All three parameters were increased in the 7 patients of subgroups 2 (skin and esophagus involvement) and 3 (skin plus multiple organ involvement), ITP was not detected in 2 patients of subgroup 1 (skin involvement only) with low ADA and CF values, Conclusion: ITP, the deamination product of ATP, is one of the clastogenic and superoxidegenerating components of CE The formation of this deamination productof ATP is probably related to the increase in ADA, CF are biomarkers of oxidative stress and can be used for evaluation of antioxidant treatments in scleroderma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:45:23