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Titolo:
EFFECTS OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE ON CONTRACTILE RESPONSES IN ISOLATED RAT AORTA
Autore:
ALOAMAKA CP; OSUBOR CC; NWANZE EAC; EBEIGBE AB;
Indirizzi:
UNIV BENIN,FAC MED,DEPT PHYSIOL,PMB 1154 BENIN CITY EDO STATE NIGERIA UNIV BENIN,FAC MED,DEPT PHYSIOL BENIN CITY EDO STATE NIGERIA UNIV BENIN,DEPT BIOCHEM BENIN CITY EDO STATE NIGERIA EDO STATE UNIV,DEPT PHYSIOL EKPOMA NIGERIA
Titolo Testata:
Methods and findings in experimental and clinical pharmacology
fascicolo: 1, volume: 19, anno: 1997,
pagine: 13 - 17
SICI:
0379-0355(1997)19:1<13:EO1OC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERIAL SMOOTH-MUSCLE; PRIMATE MODEL; MPTP; PARKINSONISM; RELAXATION; NEURONS; MOUSE; N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; NOREPINEPHRINE; NEUROTOXICITY;
Keywords:
MPTP; RAT AORTA; VASCULAR SMOOTH MUSCLE; CALCIUM; ENDOTHELIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
C.P. Aloamaka et al., "EFFECTS OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE ON CONTRACTILE RESPONSES IN ISOLATED RAT AORTA", Methods and findings in experimental and clinical pharmacology, 19(1), 1997, pp. 13-17

Abstract

The vascular effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) a meperidine analog, were studied in vitro on ring preparationsof rat aorta for the purpose of characterizing its mode of action. Isometric contractions were evaluated under standard organ bath conditions. Exposure to MPTP (10(-12) - 1.6 x 10(-8) M) did not affect basal tension but did cause dose-dependent relaxation of rings precontracted by 10(-7) M noradrenaline (NA) and was ineffective against 30 mM K+ contractions. Removal of endothelium did not significantly modify the relaxation responses. In 10(-5) M NA-stimulated (but not in 100 mM K+-stimulated) rings, MPTP significantly (p < 0.05) attenuated contractile responses to calcium chloride-following calcium-free exposure. Furthermore, the phasic contractile responses to noradrenaline in calcium-free medium (presumed to be due to mobilization of membrane bound calciumpool) were significantly (p < 0.05) attenuated by MPTP. The results suggest that MPTP relaxes rat aortic smooth muscle by a mechanism mediated, at least in part, by impairment of calcium influx through receptor-operated channels, as well as inhibition of calcium release from a membrane bound pool.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 12:16:02