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Titolo:
SYNTHESIS OF WATER-SOLUBLE BILE-PIGMENTS BOUND TO AMINE-ENDED MONOMETHOXYPOLYETHYLENEGLYCOL - THIOL ADDITION AND ATTEMPTED ENZYMATIC REDUCTION OF A BILINDIONE DERIVATIVE
Autore:
SALAMI S; MAZO A; LIGHTNER DA; TRULL FR;
Indirizzi:
UNIV BARCELONA,DEPT QUIM ORGAN,C MARTI & FRANQUES 1 E-08028 BARCELONACATALUNYA SPAIN UNIV BARCELONA,DEPT QUIM ORGAN E-08028 BARCELONA CATALUNYA SPAIN UNIV BARCELONA,DEPT BIOQUIM & BIOL MOL E-08028 BARCELONA CATALUNYA SPAIN UNIV NEVADA,DEPT CHEM RENO NV 89557
Titolo Testata:
Cellular and molecular life sciences
fascicolo: 3, volume: 53, anno: 1997,
pagine: 248 - 256
SICI:
1420-682X(1997)53:3<248:SOWBBT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR MAGNETIC-RESONANCE; BILIVERDIN REDUCTASE; CIRCULAR-DICHROISM; NEONATAL JAUNDICE; BILIRUBIN; CONFORMATION; PHOTOTHERAPY; AMIDES; DIMERS; ACID;
Keywords:
POLYETHYLENEGLYCOL AMIDE; WATER-SOLUBLE POLYMER; BILIVERDIN; BILIRUBIN; UV-VISIBLE KINETICS; THIOL ADDITION; ENZYMATIC REDUCTION; BILIVERDIN REDUCTASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
S. Salami et al., "SYNTHESIS OF WATER-SOLUBLE BILE-PIGMENTS BOUND TO AMINE-ENDED MONOMETHOXYPOLYETHYLENEGLYCOL - THIOL ADDITION AND ATTEMPTED ENZYMATIC REDUCTION OF A BILINDIONE DERIVATIVE", Cellular and molecular life sciences, 53(3), 1997, pp. 248-256

Abstract

The water-soluble amide to an NH2-ended monomethoxypolyethyleneglycol(MPEG-NH2, molecular mass of about 2000) of the dipyrrinone xanthobilirubic acid (XBR, 1) and the bis-amides of mesobiliverdiu-XIII alpha (MBV, 2) and mesobilirubin-XIII alpha (MBR, 3) have been prepared with high yields. Contrary to what is observed with biliverdin-IX alpha, 4,the enzymatic reduction of the mesobiliverdin derivative 2-MPEGA to the corresponding mesobilirubin 3-MPEGA by the soluble biliverdin reductase/NADPH system in pH 7.4 aqueous phosphate does not occur. In contrast, thiol addition to 2-MPEGA and to 4 under similar conditions is immediate, although this equilibrium is slightly less favourable for 2-MPEGA. These results enable us to discount the intrinsically low reactivity of 2-MPEGA towards thiols as the reason for its lack of enzymaticreduction, and suggest instead that this particular mesobiliverdin cannot fit properly into the enzyme binding site, either because of steric hindrance or the lack of the two propionic acid groups.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 06:46:52