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Titolo:
HERPES-SIMPLEX VIRUS AND MACROPHAGES
Autore:
SCIEUX C;
Indirizzi:
HOP ST LOUIS,UNITE VIROL,1 AVE CLAUDE VELLEFAUX F-75475 PARIS 10 FRANCE
Titolo Testata:
Pathologie et biologie
fascicolo: 2, volume: 45, anno: 1997,
pagine: 159 - 164
SICI:
0369-8114(1997)45:2<159:HVAM>2.0.ZU;2-#
Fonte:
ISI
Lingua:
FRE
Soggetto:
NECROSIS-FACTOR-ALPHA; IMMUNOSUPPRESSED MICE; INTRINSIC RESISTANCE; ANTIVIRAL ACTIVITY; GAMMA-INTERFERON; VIRAL-INFECTION; NITRIC-OXIDE; TYPE-1; REPLICATION; CELLS;
Keywords:
MACROPHAGE; HERPES SIMPLEX VIRUS; INTERFERON; CYTOKINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
C. Scieux, "HERPES-SIMPLEX VIRUS AND MACROPHAGES", Pathologie et biologie, 45(2), 1997, pp. 159-164

Abstract

Macrophages, widely distributed in the body, play a central role in mediating host defense against herpes simplex virus (HSV) infections. Both intrinsic antiviral activities of macrophages (phagocytic and degradative function leading to presentation of viral antigens, inhibitionof viral replication) and extrinsic antiviral resistance (inhibition of the spread of HSV, inhibition of HSV replication in permissive cells and selecting lysing of HSV-infected cells) are modulated by cytokines such as interferons (IFN) and tumor necrosis factor (TNF). Macrophages in the presence of an interactive network of cytokines are involved in the orchestration of non specific host defense and specific immune responses against HSV infections. Further investigations of physiopathology and complex interactions of macrophages-HSV should lead to thedevelopment of immunotherapy for HSV infections in immunocompromised individuals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 23:42:22