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Titolo:
EFFECT OF REPERFUSION ON VENTRICULAR MASS, TOPOGRAPHY, AND FUNCTION DURING HEALING OF ANTERIOR INFARCTION
Autore:
JUGDUTT BI;
Indirizzi:
UNIV ALBERTA,WALTER MACKENZIE HLTH SCI CTR 2C243,DEPT MED,DIV CARDIOLEDMONTON AB T6G 2R7 CANADA
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 3, volume: 41, anno: 1997,
pagine: 1205 - 1211
SICI:
0363-6135(1997)41:3<1205:EOROVM>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
TWO-DIMENSIONAL ECHOCARDIOGRAPHY; CORONARY-ARTERY REPERFUSION; ACUTE MYOCARDIAL-INFARCTION; CONSCIOUS DOGS; EXPANSION; NECROSIS; OCCLUSION; HYPERTROPHY; LIMITATION; SALVAGE;
Keywords:
REMODELING; SHAPE; COLLAGEN; ECHOCARDIOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
B.I. Jugdutt, "EFFECT OF REPERFUSION ON VENTRICULAR MASS, TOPOGRAPHY, AND FUNCTION DURING HEALING OF ANTERIOR INFARCTION", American journal of physiology. Heart and circulatory physiology, 41(3), 1997, pp. 1205-1211

Abstract

The effect of reperfusion performed 2 h after left. anterior descending coronary artery occlusion on in vivo changes (echocardiograms) in ventricular mass, topography, and function during postinfarction healing over 6 wk and postmortem topography (planimetry) and collagen (hydroxyproline) content at 6 wk were measured in dogs randomized to reperfusion (n = 12) and no reperfusion (n. = 12). Compared with no reperfusion over the 6 wk, reperfusion resulted in less increase in systolic and diastolic volumes, less increase in ventricular mass, less infarct wall thinning, and mild improvement in global ejection fraction withoutany change in regional asynergy. Although reperfusion decreased the infarct collagen content at 6 wk, it reduced the in vivo expansion of the endocardial surface area; the elongation, diastolic bulge, echogenicity, and systolic thinning of the infarct zone; and the global shape index and aneurysm frequency. Thus reperfusion after 2 h attenuates regional and global dilation and produces less increase in mass during postinfarct healing than no reperfusion, so that the improvement in global systolic function cannot be attributed to global hypertrophy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 14:42:46