Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
NEW MOLECULAR ASPECTS IN GASTRIC-CANCER - POSSIBLE CLINICAL IMPLICATIONS
Autore:
HOFLER H; KELLER G; CANDIDUS S; BECKER KF;
Indirizzi:
TECH UNIV MUNICH,KLINIKUM RECHTS ISAR,INST PATHOL,ISMANINGER STR 22 D-81675 MUNICH GERMANY GSF FORSCHUNGSZENTRUM UMWELT & GESUNDHEIT,INST PATHOL OBERSCHLEISSHEIM GERMANY
Titolo Testata:
Onkologie
fascicolo: 1, volume: 20, anno: 1997,
pagine: 18 - 24
SICI:
0378-584X(1997)20:1<18:NMAIG->2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-CELL-ADHESION; ALPHA-CATENIN EXPRESSION; NONPOLYPOSIS COLORECTAL-CANCER; E-CADHERIN GENE; EPIDERMAL GROWTH-FACTOR; MICROSATELLITE INSTABILITY; BETA-CATENIN; COLON-CANCER; TYROSINE PHOSPHORYLATION; IMMUNOHISTOCHEMICAL EVALUATION;
Keywords:
GASTRIC CANCER; E-CADHERIN; CATENIN; FAMILY HISTORY; MICROSATELLITE INSTABILITY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
75
Recensione:
Indirizzi per estratti:
Citazione:
H. Hofler et al., "NEW MOLECULAR ASPECTS IN GASTRIC-CANCER - POSSIBLE CLINICAL IMPLICATIONS", Onkologie, 20(1), 1997, pp. 18-24

Abstract

The investigation of molecular and genetic changes in tumor cells hasbrought new insights into the evolution of human malignancies. We have focused on the identification and characterization of genetic alterations in gastric tumors. Tight cell-cell adhesion is critical for the maintenance of epithelial differentiation, while destabilization of adhesion favors invasiveness of epithelial cells and thus carcinoma progression. The E-cadherin cell adhesion complex, composed of E-cadherin itself alpha-, beta-, and gamma-catenin, has been shown to play a major role in establishing and maintaining tight cell-cell junctions. E-cadherin and alpha-catenin expression are downregulated in various humancarcinomas. We found E-cadherin mutations in 50% of diffuse-type gastric carcinomas Loss of the wild-type allele of E-cadherin was detectedin the majority of the tumors exhibiting E-cadherin mutations, but was also found in some: intestinal-type carcinomas. No mutations in alpha- and beta-catenin cDNA were identified in gastric tumors of both types. An accumulation of mutations based on genetic instability is thought to contribute to tumor development. Microsatellite instability reflects an elevated mutation rate and was shown to be a characteristic feature of tumors in the majority of patients affected with the hereditary nonpolyposis colorectal cancer syndrome. These alterations have also been identified at a lower frequency in sporadic tumors of various organs including gastric carcinomas Interestingly, we found microsatellite instability at multiple loci in two synchronous tumors of one patient, who in addition also showed a clustering of gastric tumors in hisfamily. This may be indicative for a familial gastric carcinoma syndrome associated with a germline mutation in one of the genes involved in DNA replication accuracy. The clinical implications of all of these findings for therapy, prognosis, diagnosis, and cancer risk assessmentare discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 05:32:40