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Titolo:
LACK OF GURMARIN SENSITIVITY OF SWEET TASTE RECEPTORS INNERVATED BY THE GLOSSOPHARYNGEAL NERVE IN C57BL MICE
Autore:
NINOMIYA Y; INOUE M; IMOTO T; NAKASHIMA K;
Indirizzi:
ASAHI UNIV,SCH DENT,DEPT ORAL PHYSIOL GIFU 50102 JAPAN TOTTORI UNIV,SCH MED,DEPT PHYSIOL YONAGO TOTTORI 683 JAPAN
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 3, volume: 41, anno: 1997,
pagine: 1002 - 1006
SICI:
0363-6119(1997)41:3<1002:LOGSOS>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURAL RESPONSES; AMILORIDE; PEPTIDE; RAT; SUGARS; BUDS;
Keywords:
2 TYPES OF SWEET RECEPTORS; ANTERIOR AND POSTERIOR TONGUE REGIONS; MOUSE TASTE NERVE RESPONSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
Y. Ninomiya et al., "LACK OF GURMARIN SENSITIVITY OF SWEET TASTE RECEPTORS INNERVATED BY THE GLOSSOPHARYNGEAL NERVE IN C57BL MICE", American journal of physiology. Regulatory, integrative and comparative physiology, 41(3), 1997, pp. 1002-1006

Abstract

Effects of a sweet response inhibitor, gurmarin, on responses of the chorda tympani and glossopharyngeal nerves were studied in the C57BL/KsJ strain of mice. The lingual application of gurmarin at 3.0 mu g/ml (similar to 0.7 mu M) or more significantly suppressed chorda tympani responses to 0.5 M sucrose, as previously reported. The magnitude of gurmarin inhibition of the chorda tympani responses reached a plateau (similar to 45% of control) at 50 mu g/ml (similar to 11.9 mu M). In contrast, no such gurmarin inhibition of sucrose responses was observed in the glossopharyngeal nerve even at 100 mu g/ml (similar to 23.8 mu M). The lingual application of a proteolytic enzyme, pronase, suppressed sucrose responses to < 20% of control in both chorda tympani and glossopharyngeal nerves. These results suggest differential sensitivity to gurmarin by sweet taste receptors innervated by the chorda tympani and the glossopharyngeal nerves. The former apparently possess gurmarin sensitivity, whereas most of the latter may be lacking sensitivity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:25:40