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Titolo:
ENVIRONMENTAL ANTIANDROGENS - DEVELOPMENTAL EFFECTS, MOLECULAR MECHANISMS, AND CLINICAL IMPLICATIONS
Autore:
KELCE WR; WILSON EM;
Indirizzi:
US EPA,NATL HLTH & ENVIRONM EFFECTS RES LAB,ENDOCRINOL BRANCH,REPROD TOXICOL DIV RES TRIANGLE PK NC 27711 UNIV N CAROLINA,REPROD BIOL LABS CHAPEL HILL NC 27599 UNIV N CAROLINA,DEPT PEDIAT CHAPEL HILL NC 27599 UNIV N CAROLINA,DEPT BIOCHEM & BIOPHYS CHAPEL HILL NC 27599
Titolo Testata:
Journal of molecular medicine
fascicolo: 3, volume: 75, anno: 1997,
pagine: 198 - 207
SICI:
0946-2716(1997)75:3<198:EA-DEM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN ANDROGEN RECEPTOR; HUMAN-BREAST-CANCER; HORMONE-RESPONSIVE ELEMENTS; HUMAN PROGESTERONE-RECEPTOR; HUMAN PROSTATIC-CARCINOMA; HUMAN ESTROGEN-RECEPTOR; HUMAN X-CHROMOSOME; CONFORMATIONAL-CHANGES; STEROID BINDING; CELL-LINE;
Keywords:
ANTIANDROGEN; ENDOCRINE DISRUPTOR; SEX DIFFERENTIATION; ANDROGEN RECEPTOR; HYPOSPADIAS; BREAST CANCER; VINCLOZOLIN; 1,1-DICHLORO-2,2-BIS(P-CHLOROPHENYL) ETHYLENE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
110
Recensione:
Indirizzi per estratti:
Citazione:
W.R. Kelce e E.M. Wilson, "ENVIRONMENTAL ANTIANDROGENS - DEVELOPMENTAL EFFECTS, MOLECULAR MECHANISMS, AND CLINICAL IMPLICATIONS", Journal of molecular medicine, 75(3), 1997, pp. 198-207

Abstract

Industrial chemicals and environmental pollutants can disrupt reproductive development in wildlife and humans by mimicking or inhibiting the action of the gonadal steroid hormones, estradiol and testosterone. The toxicity of these so-called environmental endocrine disrupters is especially insidious during sex differentiation and development due tothe crucial role of gonadal steroid hormones in regulating these processes. This review describes the mechanism of toxicity and clinical implications of a new class of environmental chemicals that inhibit androgen-mediated sex development. For several of these chemicals, including the agricultural fungicide vinclozolin and the ubiquitous and persistent 1,1,1-trichloro-2,2-bis (p-chlorophenyl)ethane metabolite, 1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene, the molecular mechanism of action and the adverse developmental effects on male sex differentiation have been elucidated and are used as examples. Environmental chemicals with antiandrogenic activity offer profound implications with regard to recent clinical observations that suggest an increasing incidenceof human male genital tract malformations, male infertility, and female breast cancer. Finally, in light of increasing concern over the potential endocrine disrupting effects of environmental pollutants, an invitro/in vivo investigational strategy is presented which has proved useful in identifying chemicals with antiandrogen activity and their mechanism of action.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:38:58