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Titolo:
PTEN, A PUTATIVE PROTEIN-TYROSINE-PHOSPHATASE GENE MUTATED IN HUMAN BRAIN, BREAST, AND PROSTATE-CANCER
Autore:
LI J; YEN C; LIAW D; PODSYPANINA K; BOSE S; WANG SI; PUC J; MILIARESIS C; RODGERS L; MCCOMBIE R; BIGNER SH; GIOVANELLA BC; ITTMANN M; TYCKO B; HIBSHOOSH H; WIGLER MH; PARSONS R;
Indirizzi:
COLUMBIA UNIV,COLL PHYS & SURG,DEPT PATHOL,630 W 168 ST NEW YORK NY 10032 COLUMBIA UNIV,COLL PHYS & SURG,DEPT PATHOL NEW YORK NY 10032 COLUMBIA UNIV,COLL PHYS & SURG,DEPT MED NEW YORK NY 10032 COLD SPRING HARBOR LAB COLD SPRING HARBOR NY 11724 DUKE UNIV,MED CTR,DEPT PATHOL DURHAM NC 27710 ST JOSEPH HOSP,STEHLIN FDN CANC RES HOUSTON TX 77003 VET ADM MED CTR NEW YORK NY 10010 NYU,DEPT PATHOL NEW YORK NY 10010
Titolo Testata:
Science
fascicolo: 5308, volume: 275, anno: 1997,
pagine: 1943 - 1947
SICI:
0036-8075(1997)275:5308<1943:PAPPGM>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN GLIOMAS; REGION; IDENTIFICATION; DELETION; CLONING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
J. Li et al., "PTEN, A PUTATIVE PROTEIN-TYROSINE-PHOSPHATASE GENE MUTATED IN HUMAN BRAIN, BREAST, AND PROSTATE-CANCER", Science, 275(5308), 1997, pp. 1943-1947

Abstract

Mapping of homozygous deletions on human chromosome 10q23 has led to the isolation of a candidate tumor suppressor gene, PTEN, that appearsto be mutated at considerable frequency in human cancers. In preliminary screens, mutations of PTEN were detected in 31% (13/42) of glioblastoma cell lines and xenografts, 100% (4/4) of prostate cancer cell lines, 6% (4/65) of breast cancer cell lines and xenografts, and 17% (3/18) of primary glioblastomas. The predicted PTEN product has a proteintyrosine phosphatase domain and extensive homology to tensin, a protein that interacts with actin filaments at focal adhesions. These homologies suggest that PTEN may suppress tumor cell growth by antagonizingprotein tyrosine kinases and may regulate tumor cell invasion and metastasis through interactions at focal adhesions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:45:30