Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CYSTIC-FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR-ASSOCIATED ATP AND ADENOSINE 3'-PHOSPHATE 5'-PHOSPHOSULFATE CHANNELS IN ENDOPLASMIC-RETICULUM AND PLASMA-MEMBRANES
Autore:
PASYK EA; FOSKETT JK;
Indirizzi:
UNIV PENN,SCH MED,DEPT PHYSIOL,STELLAR CHANCE LABS,RM 313B PHILADELPHIA PA 19104 UNIV PENN,SCH MED,DEPT PHYSIOL,STELLAR CHANCE LABS PHILADELPHIA PA 19104 UNIV PENN,INST HUMAN GENE THERAPY PHILADELPHIA PA 19104 HOSP SICK CHILDREN,DIV CELL BIOL TORONTO ON M5G 1X8 CANADA
Titolo Testata:
The Journal of biological chemistry
fascicolo: 12, volume: 272, anno: 1997,
pagine: 7746 - 7751
SICI:
0021-9258(1997)272:12<7746:CTCRAA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECTIFYING CHLORIDE CHANNELS; AIRWAY ION-TRANSPORT; EPITHELIAL-CELLS; PSEUDOMONAS-AERUGINOSA; SULFATE TRANSPORT; INORGANIC SULFATE; CL CHANNEL; CFTR; GENE; MECHANISMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
E.A. Pasyk e J.K. Foskett, "CYSTIC-FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR-ASSOCIATED ATP AND ADENOSINE 3'-PHOSPHATE 5'-PHOSPHOSULFATE CHANNELS IN ENDOPLASMIC-RETICULUM AND PLASMA-MEMBRANES", The Journal of biological chemistry, 272(12), 1997, pp. 7746-7751

Abstract

Cystic fibrosis (CF) is characterized by abnormal regulation of epithelial ion and fluid transport due to mutations in the CF transmembraneconductance regulator (CFTR), an apical membrane-localized Cl- channel, that usually prevent it from exiting the endoplasmic reticulum. Defective or absent CFTR in the epithelium is believed to disrupt fluid balance in human airways and thereby contribute to chronic respiratory inflammation. Patch-clamp of the plasma membrane and outer membrane ofthe nuclear envelope of nuclei isolated from CFTR-expressing Chinese hamster ovary cells revealed that CFTR is associated with a regulated ATP channel in both membrane compartments, CFTR expression was also shown to be associated with permeability to another adenine nucleotide, adenosine 3'-phosphate 5'-phosphosulfate, the universal sulfate donor in cells. These results may provide a link between the ion channel function of CFTR and abnormal glycoprotein processing observed in CF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 15:28:48