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Titolo:
THE ROLE OF NEUROTRANSMITTERS AND NEUROHORMONES IN OBSESSIVE-COMPULSIVE DISORDER
Autore:
GREENBERG BD; ALTEMUS M; MURPHY DL;
Indirizzi:
NIMH,CLIN SCI LAB,BLDG 10,RM 3D41,10 CTR DR MSC 1264 BETHESDA MD 20892
Titolo Testata:
International review of psychiatry
fascicolo: 1, volume: 9, anno: 1997,
pagine: 31 - 44
SICI:
0954-0261(1997)9:1<31:TRONAN>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN REUPTAKE INHIBITORS; CEREBROSPINAL-FLUID NEUROCHEMISTRY; FLUOXETINE-TREATED PATIENTS; TRANSPORTER MESSENGER-RNA; DOUBLE-BLIND; META-CHLOROPHENYLPIPERAZINE; HEALTHY-VOLUNTEERS; TOURETTES-SYNDROME; NEUROENDOCRINE RESPONSES; BUSPIRONE AUGMENTATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
137
Recensione:
Indirizzi per estratti:
Citazione:
B.D. Greenberg et al., "THE ROLE OF NEUROTRANSMITTERS AND NEUROHORMONES IN OBSESSIVE-COMPULSIVE DISORDER", International review of psychiatry, 9(1), 1997, pp. 31-44

Abstract

There is considerable evidence that serotonergic systems modulate obsessive-compulsive disorder (OCD) symptomatology. The strongest such data are the antiobsessional effects of serotonin reuptake inhibitors (SRIs), unique among antidepressants. Although the mechanisms underlyingthe effectiveness of SRI treatment remain largely unknown, the available data support the position that enhanced 5-HT synaptic availability, resulting from a combination of effects on serotonin release and transport, is necessary for the therapeutic efficacy of SRI treatment. The ability of the serotonergic probe mCPP to exacerbate OCD symptoms inuntreated patients, and findings that potent 5-HT receptor antagonists may reverse SRI-induced therapeutic benefits, also support serotonergic modulation of OCD symptomatology. There is as yet little evidence that dysregulation in serotonergic systems might be etiologically important in OCD. Although evidence that other neurotransmitter or neuropeptide systems are involved in OCD is considerably more preliminary than that implicating serotonergic mechanisms, there are some indicationsthat such systems may be involved. Studies of the role of these systems, and how they may interact with serotonergic mechanisms, may be particularly helpful in further elucidating the neuropharmacology of OCD and in identifying potential new treatments.

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Documento generato il 31/03/20 alle ore 22:29:18