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Titolo:
GLOBAL ALTERATIONS IN CHROMATIN ACCESSIBILITY ASSOCIATED WITH LOSS OFSIN4 FUNCTION
Autore:
MACATEE T; JIANG YW; STILLMAN DJ; ROTH SY;
Indirizzi:
UNIV TEXAS,MD ANDERSON CANC CTR,DEPT BIOCHEM & MOL BIOL HOUSTON TX 77030 UNIV TEXAS,MD ANDERSON CANC CTR,DEPT BIOCHEM & MOL BIOL HOUSTON TX 77030 UNIV UTAH,HLTH SCI CTR,DEPT ONCOL SCI,DIV MOL BIOL & GENET SALT LAKE CITY UT 84132
Titolo Testata:
Nucleic acids research
fascicolo: 6, volume: 25, anno: 1997,
pagine: 1240 - 1247
SICI:
0305-1048(1997)25:6<1240:GAICAA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
YEAST ALPHA-2 REPRESSOR; SACCHAROMYCES-CEREVISIAE; TRANSCRIPTIONAL ACTIVATORS; HO-TRANSCRIPTION; HOMEO DOMAIN; REGULATORS; MUTATIONS; GENE; NUCLEOSOMES; RGR1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
T. Macatee et al., "GLOBAL ALTERATIONS IN CHROMATIN ACCESSIBILITY ASSOCIATED WITH LOSS OFSIN4 FUNCTION", Nucleic acids research, 25(6), 1997, pp. 1240-1247

Abstract

Sin4p is a component of a mediator complex associated with the C-terminal domain of RNA polymerase ii and SIN4 is required for proper regulation of several genes in yeast, including the HO endonuclease gene, glucose repressible genes and MATa cell-specific genes. Previous studies indicated that SIN4 may influence transcription through changes in the organization of chromatin, We have examined a specific chromatin structure associated with MAT alpha cell-specific repression in sin4 MATa cells to determine id SIN4 is required for nucleosome positioning, Although the loss of SIN4 has no effect on nucleosome location, we findthat the sensitivity of bulk chromatin from sin4 cells to micrococcalnuclease digestion is strikingly increased relative to chromatin fromisogenic wild-type cells, The nuclease hypersensitivity of chromatin from sin4 cells is not related to gross alterations in histone gene expression or to bulk Increases in histone modification, Our experimentssuggest that SIN4 directly or indirectly regulates a global aspect ofchromatin accessibility, providing a molecular basis for phenotypic similarities between sin4 mutations and mutations in histones.

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Documento generato il 26/01/21 alle ore 03:31:52