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Titolo:
RAFTK, A NOVEL MEMBER OF THE FOCAL ADHESION KINASE FAMILY, IS PHOSPHORYLATED AND ASSOCIATES WITH SIGNALING MOLECULES UPON ACTIVATION OF MATURE T-LYMPHOCYTES
Autore:
GANJU RK; HATCH WC; AVRAHAM H; ONA MA; DRUKER B; AVRAHAM S; GROOPMAN JE;
Indirizzi:
HARVARD UNIV,SCH MED,HARVARD INST MED,BETH ISRAEL DEACONESS MED CTR,DIV EXPTL MED,W CAMPUS BOSTON MA 02215 HARVARD UNIV,SCH MED,HARVARD INST MED,BETH ISRAEL DEACONESS MED CTR,DIV EXPTL MED BOSTON MA 02215 HARVARD UNIV,SCH MED,HARVARD INST MED,BETH ISRAEL DEACONESS MED CTR,DIV HEMATOL ONCOL BOSTON MA 02215 OREGON HLTH SCI UNIV,DIV HEMATOL ONCOL PORTLAND OR 97201
Titolo Testata:
The Journal of experimental medicine
fascicolo: 6, volume: 185, anno: 1997,
pagine: 1055 - 1063
SICI:
0022-1007(1997)185:6<1055:RANMOT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL ANTIGEN RECEPTOR; PROTEIN-TYROSINE KINASE; C-CBL PROTOONCOGENE; PHOSPHATIDYLINOSITOL 3-KINASE; ZETA-CHAIN; IN-VIVO; ACTIN CYTOSKELETON; JURKAT CELLS; SH3 DOMAINS; GRB2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
R.K. Ganju et al., "RAFTK, A NOVEL MEMBER OF THE FOCAL ADHESION KINASE FAMILY, IS PHOSPHORYLATED AND ASSOCIATES WITH SIGNALING MOLECULES UPON ACTIVATION OF MATURE T-LYMPHOCYTES", The Journal of experimental medicine, 185(6), 1997, pp. 1055-1063

Abstract

The related adhesion focal tyrosine kinase (RAFTK), a recently discovered member of the focal adhesion kinase family, has previously been reported to participate in signal transduction in neuronal cells, megakaryocytes, and B lymphocytes. We have found that RAFTK is constitutively expressed in human T cells and is rapidly phosphorylated upon the activation of the T cell receptor (TCR). This activation also results in an increase in the autophosphorylation and kinase activity of RAFTK. After its stimulation, there was an increase in the association of the src cytoplasmic tyrosine kinase Fyn and the adapter protein Grb2. This association was mediated through the SH2 domains of Fyn and Grb2. RAFTK also co-immunoprecipitates with the SH2 domain of Lck and with the cytoskeletal protein paxillin through its COOH-terminal proline-richdomain. The tyrosine phosphorylation of RAFTK after T cell receptor-mediated stimulation was reduced by the pretreatment of cells with cytochalasin D, suggesting the role of the cytoskeleton in this process. These observations indicate that RAFTK participates in T cell receptor signaling and may act to link signals from the cell surface to the cytoskeleton and thereby affect the host immune response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:41:46