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Titolo:
PRESYNAPTIC ALPHA(2)-ADRENOCEPTORS INHIBIT EXCITATORY SYNAPTIC TRANSMISSION IN RAT-BRAIN STEM
Autore:
BERTOLINO M; VICINI S; GILLIS R; TRAVAGLI A;
Indirizzi:
GEORGETOWN UNIV,SCH MED,DEPT PHARMACOL,3900 RESERVOIR RD NW WASHINGTON DC 20007 GEORGETOWN UNIV,SCH MED,DEPT PHYSIOL & BIOPHYS WASHINGTON DC 20007 W VIRGINIA UNIV,DEPT PHYSIOL,SCH MED MORGANTOWN WV 26506
Titolo Testata:
American journal of physiology: Gastrointestinal and liver physiology
fascicolo: 3, volume: 35, anno: 1997,
pagine: 654 - 661
SICI:
0193-1857(1997)35:3<654:PAIEST>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL MOTOR NUCLEUS; CATECHOLAMINERGIC NEURONS; VAGUS; NORADRENALINE; RECEPTORS; INVITRO; SOLITARY; MOTILITY; EFFICACY; CURRENTS;
Keywords:
BRAIN STEM SLICES; COMMISSURAL PORTION OF THE NUCLEUS TRACTUS SOLITARIUS; EXCITATORY POSTSYNAPTIC CURRENTS; L-GLUTAMATE; PATCH CLAMP; PEAK AMPLITUDE; VAGOVAGAL REFLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
M. Bertolino et al., "PRESYNAPTIC ALPHA(2)-ADRENOCEPTORS INHIBIT EXCITATORY SYNAPTIC TRANSMISSION IN RAT-BRAIN STEM", American journal of physiology: Gastrointestinal and liver physiology, 35(3), 1997, pp. 654-661

Abstract

The synaptic connection between the commissural portion of the nucleus tractus solitarius (ComNTS) and the dorsal motor nucleus of the vagus (DMV) was studied in rat brain stem slices, using the patch-clamp technique. The excitatory postsynaptic currents (EPSC) evoked by stimulation of the ComNTS were blocked by kynurenic acid (1 mM) and, in Mg2+-free solution, were sensitive to both the N-methyl-D-aspartic acid (NMDA) receptor blocker (RS)-2-carboxypiperazine-4-yl]-propyl-1-phosphonic acid (20 mu M) and the non-NMDA receptor blocker ,3-dihydro-6-nitro-7-sulfamoyl-benzo(f)quinoxaline (5 mu M). Norepinephrine (NE, 1-100 muM) inhibited the EPSC, and the inhibition was attenuated by the alpha2-adrenoceptor antagonists idazoxan (1 mu M) and yohimbine (50 mu M) but not by the beta-adrenoceptor antagonist nadolol(50 mu M) The NE-releasing agent tyramine (100 mu M) reduced the EPSC, and the inhibitionwas attenuated by 1 mu M idazoxan. NE (30 mu M) did not affect the membrane input resistance but reduced the paired-pulse depression, demonstrating that NE acts on presynaptic alpha(2)-adrenoceptors. The results indicate the existence of a glutamatergic pathway from the ComNTS to the DMV neurons modulated by presynaptic NE receptors. This pathway might be a component of the vagovagal reflex regulating gastrointestinal function.

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Documento generato il 05/06/20 alle ore 11:22:39