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Titolo:
CD18 INTEGRIN AND CD54-DEPENDENT NEUTROPHIL ADHESION TO CYTOKINE-STIMULATED HUMAN HEPATOCYTES
Autore:
NAGENDRA AR; MICKELSON JK; SMITH CW;
Indirizzi:
TEXAS CHILDRENS HOSP,CLIN CARE CTR,DEPT PEDIAT,SECT LEUKOCYTE BIOL,6621 FANNIN,MC3-2372 HOUSTON TX 77030 BAYLOR COLL MED,CARDIOL SECT,DEPT PEDIAT,SPEROS P MARTEL LAB LEUKOCYTE BIOL HOUSTON TX 77030 BAYLOR COLL MED,CARDIOL SECT,DEPT MED HOUSTON TX 77030
Titolo Testata:
American journal of physiology: Gastrointestinal and liver physiology
fascicolo: 3, volume: 35, anno: 1997,
pagine: 408 - 416
SICI:
0193-1857(1997)35:3<408:CIACNA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIA-REPERFUSION INJURY; TUMOR-NECROSIS-FACTOR; MAC-1 CD11B/CD18; KUPFFER CELLS; ENDOTHELIAL-CELLS; RAT-LIVER; TRANSENDOTHELIAL MIGRATION; CARDIAC MYOCYTES; HEPATIC ISCHEMIA; GENE-EXPRESSION;
Keywords:
INTERFERON-GAMMA; INTERLEUKIN-1-BETA; TUMOR NECROSIS FACTOR-ALPHA; CHEMOTACTIC FACTORS; INTERLEUKIN-8;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
A.R. Nagendra et al., "CD18 INTEGRIN AND CD54-DEPENDENT NEUTROPHIL ADHESION TO CYTOKINE-STIMULATED HUMAN HEPATOCYTES", American journal of physiology: Gastrointestinal and liver physiology, 35(3), 1997, pp. 408-416

Abstract

We investigated the hypothesis that CD54 (intercellular adhesion molecule-1) expressed on hepatocytes will support beta(2)-integrin (CD18)-dependent adhesion of neutrophils. An in vitro model using C3A cells (a human hepatoblastoma cell line exhibiting many characteristics of normal hepatocytes) and human neutrophils was utilized. C3A cells were stimulated with interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha, or interferon-gamma (IFN-gamma) far 24 h to induce expression ofCD54, and adhesion of neutrophils was found to be markedly increased. Detailed studies with IFN-gamma-stimulated (100 U/ml) C3A cells revealed that this adhesion involved CD11a/CD18 [lymphocyte function-associated antigen-1 (LFA-1)] and CD54 and was dependent on low levels of IL-8 produced by the stimulated hepatocytes. Addition of higher concentrations of chemotactic factor (e.g., IL-8) further augmented adhesion and recruited contributions of CD11b/CD18 (Mac-1). In contrast to LFA-1, Mac-1 appeared to recognize a CD54-independent ligand constitutivelyexpressed on the hepatocytes. Such close apposition of neutrophils tohepatocytes may increase the potential for parenchymal cell injury byproviding a short distance through which cytotoxic factors such as reactive oxygen or proteolytic enzymes could act.

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Documento generato il 23/01/21 alle ore 03:07:02