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Titolo:
EFFICIENCY OF KETANSERIN IN POSTANESTHETI C SHIVERING
Autore:
CRISINEL D; BISSONNETTE B; FEIHL F; GARDAZ JP;
Indirizzi:
CHU VAUDOIS,ANESTHESIOL SERV CH-1011 LAUSANNE SWITZERLAND CHU VAUDOIS,ANESTHESIOL SERV CH-1011 LAUSANNE SWITZERLAND
Titolo Testata:
Annales francaises d'anesthesie et de reanimation
fascicolo: 2, volume: 16, anno: 1997,
pagine: 120 - 125
SICI:
0750-7658(1997)16:2<120:EOKIPC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
FRE
Soggetto:
THERMOREGULATORY THRESHOLD; HUMANS; ANESTHESIA; CLONIDINE; FENTANYL; HEAT;
Keywords:
COMPLICATIONS, SHIVERING; AUTONOMIC NERVOUS SYSTEM; 5-HT2 ANTAGONIST; KETANSERIN; MEASUREMENT TECHNIQUES, ELECTROMYOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
D. Crisinel et al., "EFFICIENCY OF KETANSERIN IN POSTANESTHETI C SHIVERING", Annales francaises d'anesthesie et de reanimation, 16(2), 1997, pp. 120-125

Abstract

Objective: To evaluate the clinical and electromyographic (EMG) effects of ketanserin (K), a serotoninergic receptor antagonist (5-HT2), onpostoperative shivering (POS). Study design: Prospective, randomised,double-blind study. Patients: Fifty ASA class 1 and 2 patients with major clinical postoperative tremor were studied. Methods: POS was assessed clinically (0 = nil, 1 = moderate, 2 = severe). Inclusion criterion was a POS of 2 at admission in the recovery room. The mean arterialblood pressure, rectal temperature, SpO(2) were recorded at admission(T0) and subsequently at T5, T10, T15, T30 and T60 minutes. Either 10mg of K (n = 25) ora corresponding volume of a placebo (P) (n = 25) were intravenously injected. The EMG activity of the deltoid and quadriceps muscles was recorded continuously. Blood lactic acid concentration was measured at the end of POS. Results are expressed as mean +/- SEM. Parametric values were analysed with unpaired Students t-test, and nonparametric values with chi(2) analysis. P < 0.05 was accepted. Results: Demographic data, duration of anaesthesia, postoperative temperature, oxygen saturation, blood pressure and blood lactate concentrationwere similar between groups. The POS duration in the K group was significantly shorter than in the P group: 8.8 +/- 1.5 min and 15.5 +/- 1.5 min respectively (P < 0.01). The number of patients in the K group experiencing POS at T5 and T10 was significantly lower, when compared With those who had received the P (P < 0.05).Conclusion: At a dose of 10 mg, K administered in patients with POS during recovery, reduced significantly the duration and intensity of the shivering without noticeable side effects. This study suggests that this 5-HT2 antagonist is anefficient therapeutic tool for POS in adults.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 00:39:07