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Titolo:
RESISTANCE OF TNF L T-ALPHA DOUBLE DEFICIENT MICE TO BLEOMYCIN-INDUCED FIBROSIS/
Autore:
PIGUET PF; KAUFMAN S; BARAZZONE C; MULLER M; RYFFEL B; EUGSTER HP;
Indirizzi:
UNIV GENEVA,DEPT PATHOL CH-1211 GENEVA SWITZERLAND AMGEN INC THOUSAND OAKS CA 91320 INST TOXICOL CH-8603 ZURICH SWITZERLAND UNIV BASEL,DEPT PATHOL CH-4003 BASEL SWITZERLAND
Titolo Testata:
International journal of experimental pathology
fascicolo: 1, volume: 78, anno: 1997,
pagine: 43 - 48
SICI:
0959-9673(1997)78:1<43:ROTLTD>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; PULMONARY FIBROSIS; LUNG; COLLAGEN; GROWTH;
Keywords:
TNF; FIBROSIS; BLEOMYCIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
P.F. Piguet et al., "RESISTANCE OF TNF L T-ALPHA DOUBLE DEFICIENT MICE TO BLEOMYCIN-INDUCED FIBROSIS/", International journal of experimental pathology, 78(1), 1997, pp. 43-48

Abstract

In order to evaluate the role and mode of action of TNF in bleomycin-induced lung fibrosis, mice deficient for TNF and LT alpha (Delta TNF/LT alpha) were examined at 2 months of age and after 3 weekly i.v. injections of bleomycin. The body weight of the Delta TNF/LT alpha mice was 88 +/- 11% of that of the wild type littermates. Lung collagen, evaluated by its hydroxyproline content, was also lower (81 +/- 9%) in mutant than in wild type littermates. Bleomycin induced a diffuse alveolitis with focal areas of alveolar remodelling in wild type but not in Delta TNF/LT alpha, mice. Lymphoid infiltration was also prominent in wild type, but absent from Delta TNF/LT alpha, mice. Bleomycin injections increased collagen deposition, as evaluated by the lung hydroxyproline content, more markedly in wild type, than in Delta TNF/LT alpha, mice. Cell trapping in the alveolar capillaries was evaluated by semi-quantitative electron microscopy. Bleomycin markedly increased platelet trapping in the alveolar capillaries of wild type, but not of Delta TNF/LT alpha, mice. This study indicates that the expression of TNF/LTalpha genes increases the deposition of collagen in both untreated and inflamed lung and that these genes may act, at least in part, by promoting platelet trapping.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 02:58:44