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Titolo:
POSITRON EMISSION TOMOGRAPHY MEASUREMENT OF CEREBRAL METABOLIC CORRELATES OF YOHIMBINE ADMINISTRATION IN COMBAT-RELATED POSTTRAUMATIC-STRESS-DISORDER
Autore:
BREMNER JD; INNIS RB; NG CK; STAIB LH; SALOMON RM; BRONEN RA; DUNCAN J; SOUTHWICK SM; KRYSTAL JH; RICH D; ZUBAL G; DEY H; SOUFER R; CHARNEY DS;
Indirizzi:
W HAVEN VET AFFAIRS MED CTR,950 CAMPBELL AVE W HAVEN CT 06516 YALE UNIV,SCH MED,DEPT PSYCHIAT NEW HAVEN CT 00000 YALE UNIV,SCH MED,DEPT DIAGNOST RADIOL NEW HAVEN CT 06510 NATL CTR POSTTRAUMAT STRESS DISORDER W HAVEN CT 00000 YALE VET AFFAIRS POSITRON EMISS TOMOG CTR W HAVEN CT 00000
Titolo Testata:
Archives of general psychiatry
fascicolo: 3, volume: 54, anno: 1997,
pagine: 246 - 254
SICI:
0003-990X(1997)54:3<246:PETMOC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCUS COERULEUS NEURONS; BLOOD-FLOW; PANIC DISORDER; NORADRENERGIC FUNCTION; VIETNAM VETERANS; PHYSIOLOGICAL-RESPONSES; NORADRENALINE TURNOVER; URINARY NOREPINEPHRINE; ENVIRONMENTAL STIMULI; BRAIN-REGIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
100
Recensione:
Indirizzi per estratti:
Citazione:
J.D. Bremner et al., "POSITRON EMISSION TOMOGRAPHY MEASUREMENT OF CEREBRAL METABOLIC CORRELATES OF YOHIMBINE ADMINISTRATION IN COMBAT-RELATED POSTTRAUMATIC-STRESS-DISORDER", Archives of general psychiatry, 54(3), 1997, pp. 246-254

Abstract

Background: We have previously reported an increase in symptoms of anxiety in patients with posttraumatic stress disorder (PTSD) following administration of the beta(2)-antagonist yohimbine, which stimulates brain norepinephrine release. Preclinical studies show decreased metabolism in the neocortex and the caudate nucleus with high-dose yohimbine-induced norepinephrine release, but low levels of norepinephrine release result in an increase in metabolism in these areas. Methods: We used positron emission tomography and fludeoxyglucose F 18 to measure brain metabolism in Vietnam combat veterans with PTSD (n=10) and healthyage-matched control subjects (n=10), following administration of yohimbine (0.4 mg/kg) or placebo in a randomized, double-blind fashion. Results: Yohimbine resulted in a significant increase in anxiety in the patients with PTSD, but not in healthy subjects. There was a significant difference in brain metabolic response to yohimbine in patients with PTSD compared with healthy subjects in prefrontal, temporal, parietal, and orbitofrontal cortexes. Metabolism tended to decrease in patients with PTSD and increase in healthy subjects following administrationof yohimbine. Conclusion: These findings are consistent with our previous hypothesis of enhanced norepinephrine release in the brain with yohimbine in patients with PTSD.

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Documento generato il 05/04/20 alle ore 19:36:06