Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
COMPARISON OF ALBUMIN-(GD-DTPA)(30) AND GD-DTPA-24-CASCADE-POLYMER FOR MEASUREMENTS OF NORMAL AND ABNORMAL MICROVASCULAR PERMEABILITY
Autore:
ROBERTS HC; SAEED M; ROBERTS TPL; MUHLER A; SHAMES DM; MANN JS; STISKAL M; DEMSAR F; BRASCH RC;
Indirizzi:
UNIV CALIF SAN FRANCISCO,DEPT RADIOL SAN FRANCISCO CA 94143
Titolo Testata:
Journal of magnetic resonance imaging
fascicolo: 2, volume: 7, anno: 1997,
pagine: 331 - 338
SICI:
1053-1807(1997)7:2<331:COAAGF>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
DTPA-CASCADE-POLYMER; GD-DTPA; CONTRAST AGENT; GADOLINIUM-DTPA; CAPILLARY-PERMEABILITY; ENHANCING AGENT; BLOOD-VESSELS; SOLID TUMORS; BREAST; RAT;
Keywords:
MICROVASCULAR PERMEABILITY; MACROMOLECULAR CONTRAST AGENT MAGNETIC RESONANCE IMAGING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
H.C. Roberts et al., "COMPARISON OF ALBUMIN-(GD-DTPA)(30) AND GD-DTPA-24-CASCADE-POLYMER FOR MEASUREMENTS OF NORMAL AND ABNORMAL MICROVASCULAR PERMEABILITY", Journal of magnetic resonance imaging, 7(2), 1997, pp. 331-338

Abstract

The purpose of this study was to compare a new MR macromolecular contrast medium (MMCM), gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA)-24-cascade-polymer, to a well-studied prototype MMCM, for the potential of distinguishing tissues of varying endothelial permeability. Three tissue models of varying capillary permeability were studied in a total of 46 rats: normal myocardium (normal capillaries), subcutaneously implanted adenocarcinoma (mild capillary leak), and reperfused infarcted myocardium (high capillary leak). T1-weighted MRI was performed before and dynamically after injection of either albumin-((Gd-DTPA)(30) or the cascade polymer (each .02 mmol gadolinium [Gd] per kg). Data analysis based on a two-compartment kinetic model yielded estimates of fractional blood volume (BV) (percentage) and fractional leak rate (FLR) (1 per hour). Permeability to the cascade polymer as reflectedin FLR was considerable in normal myocardium (8.24 per hour), of similar value in tumors (8.55 per hour), but significantly greater in infarcted myocardium (39.17 per hour, P < .01) versus normal myocardium. The larger albumin-(Gd-DTPA)(30) demonstrated minimal extravasation in normal myocardium (FLR.33 per hour); FLR in tumors was 100% higher (.66 per hour, P < .002) and FLR in reperfused capillaries was significantly greater (7.94 per hour, P < .001). Based on capillary permeabilitymeasurements, the cascade polymer may have limited utility for detection of mildly increased microvascular permeabilities. For severe tissue injury, the cascade polymer can resolve abnormal microvascular integrity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 22:59:16