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Titolo:
THYMIC NURSE CELLS - ENTRY OF EXOGENOUS HORSERADISH-PEROXIDASE VIA A TRANSCYTOTIC ROUTE
Autore:
WIEMANN M; EHRET G;
Indirizzi:
UNIV ESSEN GESAMTHSCH,INST PHYSIOL,HUFELANDSTR 55 D-45122 ESSEN GERMANY UNIV ULM,ABT VERGLEICHENDE NEUROBIOL D-89069 ULM GERMANY
Titolo Testata:
Acta anatomica
fascicolo: 1, volume: 157, anno: 1996,
pagine: 20 - 26
SICI:
0001-5180(1996)157:1<20:TNC-EO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPITHELIAL-CELLS; DIFFERENTIATION; MICROENVIRONMENT; LOCALIZATION; THYMOCYTES; COMPLEXES; BINDING; MOUSE;
Keywords:
THYMIC EPITHELIUM; THYMIC NURSE CELLS; TRANSCYTOSIS; MOUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
M. Wiemann e G. Ehret, "THYMIC NURSE CELLS - ENTRY OF EXOGENOUS HORSERADISH-PEROXIDASE VIA A TRANSCYTOTIC ROUTE", Acta anatomica, 157(1), 1996, pp. 20-26

Abstract

In order to address the question whether thymocytes inside thymic nurse cells (TNCs) are secluded against exogenous proteins, TNCs were isolated and kept in the presence of horseradish peroxidase. The distribution of horseradish peroxidase reaction product (HRP) within the TNCs was studied by light (LM) and electron microscopy (EM). Stained and unstained TNCs could be distinguished by LM. At the EM level, stained TNCs had a widened lumen and HRP lined the luminal surfaces. In unstained TNCs the lumen appeared normal and contained almost no HRP. In both types of TNCs the epithelial cell contained HRP in endosomes and, together with cellular debris, in larger vacuoles. Exocytosis of the latter was observed. Conglomerates of HRP were found inside the lumen and also within thymocytes. Data suggested that TNCs can shield secluded thymocytes against exogenous proteins except these which are provided bya transcytotic pathway. Such a pathway has not been demonstrated before in TNCs.

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Documento generato il 02/12/20 alle ore 05:29:00