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Titolo:
SENSORY INNERVATION OF THE GUINEA-PIG EXTRAOCULAR-MUSCLES - A '-DIOCTADECYL-3,3,3'3'-TETRAMETHYLINDOCARBOCYANINE PERCHLORATE TRACING AND CALCITONIN-GENE-RELATED PEPTIDE IMMUNOHISTOCHEMICAL STUDY
Autore:
AIGNER M; LUKAS JR; DENK M; MAYR R;
Indirizzi:
UNIV VIENNA,INST ANAT 2,WAHRINGERSTR 13 A-1090 VIENNA AUSTRIA UNIV VIENNA,DEPT OPHTHALMOL,SECT A A-1090 VIENNA AUSTRIA
Titolo Testata:
Journal of comparative neurology
fascicolo: 1, volume: 380, anno: 1997,
pagine: 16 - 22
SICI:
0021-9967(1997)380:1<16:SIOTGE>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL-ROOT-GANGLIA; PRIMARY AFFERENT NEURONS; EXTRA-OCULAR MUSCLES; TRIGEMINAL GANGLION; SUBSTANCE-P; HORSERADISH-PEROXIDASE; RETROGRADE TRANSPORT; MONOCLONAL-ANTIBODY; OCULOMOTOR NERVE; CO-EXISTENCE;
Keywords:
CALCITONIN GENE-RELATED PEPTIDE; TRIGEMINAL GANGLION; PRIMARY AFFERENT NEURONS; POSTMORTEM NEURONAL TRACING; IMMUNOHISTOCHEMISTRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
M. Aigner et al., "SENSORY INNERVATION OF THE GUINEA-PIG EXTRAOCULAR-MUSCLES - A '-DIOCTADECYL-3,3,3'3'-TETRAMETHYLINDOCARBOCYANINE PERCHLORATE TRACING AND CALCITONIN-GENE-RELATED PEPTIDE IMMUNOHISTOCHEMICAL STUDY", Journal of comparative neurology, 380(1), 1997, pp. 16-22

Abstract

The sensory apparatus of the extraocular muscles attains special interest because of the great variation among different species with respect to the proprioceptors, The sensory innervation of the guinea pig extraocular muscles, lacking both muscle spindles and tendon organs, wasinvestigated with a fluorescence double-labelling method. Primary sensory perikarya were assessed by postmortem application of -dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (Di-I) to the extraocular muscle nerves. Traced neurons were found in the ipsilateral ophthalmic part of the trigeminal ganglion. This is in line with findingsin other species. Calcitonin gene-related peptide (CGRP) was detectedimmunohistochemically within the trigeminal ganglion. No somatotopic organization was observed for CGRP-like immunoreactive perikarya. Small (maximal diameter below 30 mu m), medium (maximal diameter between 30 and 50 mu m), and large (maximal diameter larger than 50 mu m) trigeminal ganglion cells were found among the primary afferent perikarya from extraocular muscles. Among CGRP-like immunoreactive cells, only small and medium cells were observed. Double-labelling experiments indicated the CGRP content of primary afferents of the guinea pig extraocular muscles. The relationship to former morphological categories of ganglion cells is discussed. Primary afferent neurons with CGRP-like immunoreactivity might have efferent functions and might also be involved in inflammatory processes of extraocular muscles. (C) 1997 Wiley-Liss,Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 18:35:07