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Titolo:
SMOKING AND BRONCHIAL RESPONSIVENESS IN NONATOPIC AND ATOPIC YOUNG-ADULTS
Autore:
SUNYER J; ANTO JM; KOGEVINAS M; SORIANO JB; TOBIAS A; MUNOZ A; MARTINEZMORATALLA J; ALMAR E; AREVALO M; MATEOS A; SANCHEZ A; VIZCAYA M; BURGOS F; CASTELLSAGUE J; ROCA J; MUNIOZGUREN N; ERRAZOLA M; CAPELASTEGUI A; RAMOS J; MALDONADO JA; SANCHEZ JL; PEREIRA A; GRAVALOS J; QUIROS R; AZOFRA J; PALENCIANO L; PAYO F; REGO G; VEGA A;
Indirizzi:
INST MUNICIPAL INVEST MED,DEPT EPIDEMIOL & SALUT PUBL,DR AIGUADER 80 E-08003 BARCELONA SPAIN JOHNS HOPKINS UNIV,SCH PUBL HLTH,DEPT EPIDEMIOL BALTIMORE MD 21205
Titolo Testata:
Thorax
fascicolo: 3, volume: 52, anno: 1997,
pagine: 235 - 238
SICI:
0040-6376(1997)52:3<235:SABRIN>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CIGARETTE SMOKERS; ASTHMA; METHACHOLINE; REACTIVITY; POPULATION; COMMUNITY; HISTAMINE; IMMUNE; HABITS; SEX;
Keywords:
SMOKING; ATOPY; BRONCHIAL RESPONSIVENESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
J. Sunyer et al., "SMOKING AND BRONCHIAL RESPONSIVENESS IN NONATOPIC AND ATOPIC YOUNG-ADULTS", Thorax, 52(3), 1997, pp. 235-238

Abstract

Background - Smoking may influence the response of the lungs to otherinhaled substances. A study was undertaken to assess the effect of the interaction between smoking and the immunoresponse to common aeroallergens (atopy) on bronchial responsiveness. Methods - A random sample was selected from the general population census of five areas of Spain(Albacete, Barcelona, Galdakao, Huelva, and Oviedo). A total of 1169 (35%) subjects completed a face-to-face respiratory questionnaire, a methacholine bronchial responsiveness challenge, and underwent measurements of total and specific serum IgE levels to mites, pets and moulds. A survival model (Weibull) was used to examine the methacholine dose-response relation, adjusting for bronchial obstruction. Results - Smokers showed greater bronchial responsiveness than never smokers (p <0.05) at any dose of methacholine, but only among non-atopic individuals. Atopy had a large effect on responsiveness at low levels of methacholine, but smoking did not increase responsiveness in atopic subjects. There were no differences in intensity or cessation of smoking between atopic and non-atopic subjects, suggesting that smoking self-selectiondoes not fully explain these results. Conclusions - The association between smoking and bronchial responsiveness varies with atopy, which may be explained by different immunological and/or inflammatory effectsof smoking on atopy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 20:33:52