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Titolo:
COMPLEX CHROMOSOME-4, CHROMOSOME-9, AND CHROMOSOME-22 REARRANGEMENT IN A PATIENT PRESENTING WITH AML-FAB M2
Autore:
MARTIN ES; JOSEPH A; AHMAD MA; BORGAONKAR DS; MARTIN SE;
Indirizzi:
MED CTR DELAWARE,CYTOGENET LAB,DEPT LAB MED & PATHOL,POB 6001 NEWARK DE 19718 MED CTR DELAWARE,CYTOGENET LAB,DEPT LAB MED & PATHOL NEWARK DE 19718 MED CTR DELAWARE,BONE MARROW TRANSPLANTAT PROGRAM NEWARK DE 19718
Titolo Testata:
Cancer genetics and cytogenetics
fascicolo: 2, volume: 93, anno: 1997,
pagine: 119 - 124
SICI:
0165-4608(1997)93:2<119:CCCACR>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC MYELOGENOUS LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; CHRONIC MYELOID-LEUKEMIA; POSITIVE ACUTE-LEUKEMIA; PHILADELPHIA-CHROMOSOME; C-ABL; BCR REARRANGEMENT; TRANSFORMATION; TRANSLOCATIONS; DIAGNOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
E.S. Martin et al., "COMPLEX CHROMOSOME-4, CHROMOSOME-9, AND CHROMOSOME-22 REARRANGEMENT IN A PATIENT PRESENTING WITH AML-FAB M2", Cancer genetics and cytogenetics, 93(2), 1997, pp. 119-124

Abstract

Fluorescence in situ hybridization FISH) and the reverse transcription-polymerase chain reaction (RT-PCR) were used to examine a patient presenting with acute myelogenous leukemia (AML) FAB M2, and a complex t(4;9;22)(p14;q34;q11.2). The patient's clinical course was characterized by an aggressive leukemia, resistant to intensive therapy includingallogeneic bone marrow transplantation. FISH analysis, using two chromosome painting probes and a BCR/ABL specific probe, confirmed the cytogenetic observation of a 22q11.2-->4p14 and a 4p14-->9q34 exchange, and revealed the presence of a 9q34-->22q11.2, respectively. In addition, RT-PCR demonstrated the presence of a BCR/ABL transcript derived from the major breakpoint cluster region (M-bcr) of the BCR gene. This transcript has been shown to generate an active 210 kDa tyrosine kinaseprotein more commonly observed in chronic myelogenous leukemia. Because the presentation of AML with this ABL-->BCR fusion product is a rare event, it would seem likely that the additional complex chromosomal rearrangement involving chromosomes 4, 9, and 22 played a role in the aggressive presentation and clinical behavior of this patient's leukemia. (C) Elsevier Science Inc., 1997.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 21:59:58