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Titolo:
EXPRESSION OF MESSENGER-RNAS CODING FOR THE TRANSFORMING GROWTH-FACTOR-BETA RECEPTORS IN BRAIN-REGIONS OF EUTHYROID AND HYPOTHYROID NEONATAL RATS AND IN ADULT BRAIN
Autore:
SLOTKIN TA; WANG XF; SYMONDS HS; SEIDLER FJ;
Indirizzi:
DUKE UNIV,MED CTR,DEPT PHARMACOL,BOX 3813 DURHAM NC 27710
Titolo Testata:
Developmental brain research
fascicolo: 1, volume: 99, anno: 1997,
pagine: 61 - 65
SICI:
0165-3806(1997)99:1<61:EOMCFT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROID-HORMONE; II RECEPTOR; HEART DEVELOPMENT; GENE-EXPRESSION; HYPERTHYROIDISM; ONTOGENY; KIDNEY;
Keywords:
PROPYLTHIOURACIL, EFFECTS ON TGF-P RECEPTOR EXPRESSION; THYROID HORMONE, ROLE IN DEVELOPMENT OF TGF-P RECEPTOR MESSENGER-RNA; TRANSFORMING GROWTH FACTOR-BETA RECEPTORS, IN DEVELOPING BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
T.A. Slotkin et al., "EXPRESSION OF MESSENGER-RNAS CODING FOR THE TRANSFORMING GROWTH-FACTOR-BETA RECEPTORS IN BRAIN-REGIONS OF EUTHYROID AND HYPOTHYROID NEONATAL RATS AND IN ADULT BRAIN", Developmental brain research, 99(1), 1997, pp. 61-65

Abstract

The TGF-beta family of peptides has been postulated to play a role incontrol of the cell cycle but also may act in the developing brain toinfluence neuronal differentiation and survival. Because reception ofTGF-beta signals requires the simultaneous expression of all three known receptor subtypes, we examined two neonatal rat brain regions in which neurogenesis has been largely completed. mRNA coding for all three receptors was detectable in both the forebrain and brainstem but only the type II receptor in brainstem showed a difference from adult levels of expression. Animals given perinatal PTU treatment to achieve congenital cretinism did not show significant differences in expression of any of the receptor subtypes in either of the regions, despite the fact that the treatment is known to cause anomalies of neuronal differentiation. These results indicate that regions in which neurons are undergoing axonogenesis and synaptogenesis rather than neurogenesis, nevertheless express the mRNAs coding for TGF-beta receptors and are thuslikely to be receptive to trophic signals mediated through TGF-beta. However, synthesis and release of TGF-beta, rather than receptor expression per se, is more likely to be the major point for regulation of signaling. The potential roles of TGF-beta in developmental events outside of the cell cycle, such as synaptogenesis and apoptosis, need to be examined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:04:46