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Titolo:
DEVELOPMENTAL DYNAMICS OF FUNCTIONALLY SPECIFIC PRIMARY SENSORY AFFERENT-PROJECTIONS IN THE CHICKEN-EMBRYO
Autore:
EIDE AL; GLOVER JC;
Indirizzi:
UNIV OSLO,INST BASIC MED SCI,DEPT PHYSIOL,PB 1103 BLINDERN N-0317 OSLO NORWAY UNIV OSLO,INST BASIC MED SCI,DEPT ANAT N-0317 OSLO NORWAY
Titolo Testata:
Anatomy and embryology
fascicolo: 3, volume: 195, anno: 1997,
pagine: 237 - 250
SICI:
0340-2061(1997)195:3<237:DDOFSP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL-ROOT GANGLION; MYELIN-ASSOCIATED GLYCOPROTEIN; GALLUS-GALLUS-DOMESTICUS; LUMBOSACRAL SPINAL-CORD; NERVE GROWTH-FACTOR; NEURAL CREST; FIBER COLLATERALS; DIFFERENTIATION ANTIGENS; HORSERADISH-PEROXIDASE; PRECURSOR CELLS;
Keywords:
DRG; SYNAPSE FORMATION; SPINAL CORD; DII; AXON GROWTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
79
Recensione:
Indirizzi per estratti:
Citazione:
A.L. Eide e J.C. Glover, "DEVELOPMENTAL DYNAMICS OF FUNCTIONALLY SPECIFIC PRIMARY SENSORY AFFERENT-PROJECTIONS IN THE CHICKEN-EMBRYO", Anatomy and embryology, 195(3), 1997, pp. 237-250

Abstract

The central projections of specific subpopulations of lumbar primary afferents were selectively labeled with the lipophilic tracer DiI in fixed preparations of the chicken embryo. Muscle or cutaneous afferentswere selectively labeled by applying DiI to identified peripheral nerves. Medial or lateral afferent populations were selectively labeled by partially lesioning the dorsal root. Muscle and cutaneous afferent populations each contribute to both the medial and the lateral afferentpopulations. Medial muscle afferents terminate in the intermediate zone and lateral motor column proximally, but only in the intermediate zone distally. Lateral muscle afferents terminate in a ventrolateral region of the dorsal horn both proximally and distally. Medial cutaneousafferents terminate predominantly in lamina III, but a few terminate in the medial region of the intermediate zone. Lateral cutaneous afferents terminate in lamina II and in a ventrolateral region of the dorsal horn. On the basis of the principle termination patterns, specific termination fields were defined and related to the classical cytoarchitectonics of the spinal gray matter. Differential retrograde tracing from the spinal cord with fluorescent dextran-amines demonstrated that the medial afferents originate from the earlier-generated ventrolateralpopulation of large sensory cell bodies, while the lateral afferents originate from the later-generated dorsomedial population of small sensory cell bodies. The medial afferents establish their central projections earlier than the lateral afferents, but for each subpopulation the initial pattern of termination prefigures the mature pattern, throughout the segmental range of the collaterals. Birthdating with H-3-thymidine showed that potential target neurons in the different terminal fields within the dorsal horn are born at different times. In particular, interneurons in lamina II are born after those in lamina III, paralleling the early and late termination of cutaneous afferents in these laminae. Our observations support the notion that primary afferents recognize specific cues in the spinal cord, but also implicate the relative timing of afferent and target differentiation as an important determinant of primary afferent termination patterns.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 06:05:00