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Titolo:
ENDOGENOUS SYNTHESIS OF N-METHYLNORSALSOLINOL IN RAT-BRAIN DURING IN-VIVO MICRODIALYSIS WITH EPININE
Autore:
KAJITA M; NIWA T; MARUYAMA W; NAKAHARA D; TAKEDA N; YOSHIZUMI H; TATEMATSU A; WATANABE K; NAOI M; NAGATSU T;
Indirizzi:
NAGOYA UNIV,SCH MED,DEPT PEDIAT,SHOWA KU NAGOYA AICHI 466 JAPAN NAGOYA UNIV,BRANCH HOSP,DEPT INTERNAL MED,HIGASHI KU NAGOYA 461 JAPAN NAGOYA UNIV,SCH MED,DEPT NEUROL,SHOWA KU NAGOYA AICHI 466 JAPAN NAGOYA UNIV,COLL MED TECHNOL,DEPT PSYCHOL NAGOYA 461 JAPAN MEIJO UNIV,FAC PHARM,TEMPAKU KU NAGOYA 468 AICHI JAPAN NAGOYA INST TECHNOL,DEPT BIOSCI,SHOWA KU NAGOYA AICHI 466 JAPAN FUJITA HLTH UNIV,SCH MED,INST COMPREHENS MED SCI,DIV GENET NEUROCHEM 2 TOYOAKE AICHI 47011 JAPAN
Titolo Testata:
Journal of chromatography B. Biomedical applications
fascicolo: 2, volume: 654, anno: 1994,
pagine: 263 - 269
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMATOGRAPHY MASS-SPECTROMETRY; INVIVO MICRODIALYSIS; PARKINSONISM; DOPAMINE; ANALOG;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
M. Kajita et al., "ENDOGENOUS SYNTHESIS OF N-METHYLNORSALSOLINOL IN RAT-BRAIN DURING IN-VIVO MICRODIALYSIS WITH EPININE", Journal of chromatography B. Biomedical applications, 654(2), 1994, pp. 263-269

Abstract

The in vivo metabolic pathway for the synthesis of N-methylnorsalsolinol, an analogue of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), was studied in the rat brain. N-Methyldopamine (epinine) was perfused at the striatum of the rat brain by in vivo microdialysis. N-Methylnorsalsolinol (NMNSAL) was identified in the brain dialysate after epinine perfusion using gas chromatography-serected-ion monitoring mass spectrometry (GC-SIMMS). We demonstrated that NMNSAL could be synthesized from epinine with an aldehyde by the Piclet-Spengler condensation reaction in the rat brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 14:11:44