Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
NEONATAL TREATMENT OF RATS WITH THE NEUROACTIVE STEROID TETRAHYDRODEOXYCORTICOSTERONE (THDOC) ABOLISHES THE BEHAVIORAL AND NEUROENDOCRINE CONSEQUENCES OF ADVERSE EARLY-LIFE EVENTS
Autore:
PATCHEV VK; MONTKOWSKI A; ROUSKOVA D; KORANYI L; HOLSBOER F; ALMEIDA OFX;
Indirizzi:
MAX PLANCK INST PSYCHIAT,INST CLIN,DEPT NEUROENDOCRINOL,KRAEPELINSTR 2 D-80804 MUNICH GERMANY HAYNAL UNIV HLTH SCI,POSTGRAD MED SCH,DEPT CLIN & EXPT LAB MED H-1135BUDAPEST HUNGARY
Titolo Testata:
The Journal of clinical investigation
fascicolo: 5, volume: 99, anno: 1997,
pagine: 962 - 966
SICI:
0021-9738(1997)99:5<962:NTORWT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; GENE-EXPRESSION; MESSENGER-RNA; STRESS-RESPONSE; A RECEPTOR; YOUNG-RATS; ADULT-RATS; SEPARATION; BRAIN; HORMONE;
Keywords:
NEUROSTEROID; MATERNAL SEPARATION; CORTICOSTERONE; CORTICOTROPIN-RELEASING HORMONE; GLUCOCORTICOID RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
V.K. Patchev et al., "NEONATAL TREATMENT OF RATS WITH THE NEUROACTIVE STEROID TETRAHYDRODEOXYCORTICOSTERONE (THDOC) ABOLISHES THE BEHAVIORAL AND NEUROENDOCRINE CONSEQUENCES OF ADVERSE EARLY-LIFE EVENTS", The Journal of clinical investigation, 99(5), 1997, pp. 962-966

Abstract

Stressful experience during early brain development has been shown toproduce profound alterations in several mechanisms of adaptation, while several signs of behavioral and neuroendocrine impairment resultingfrom neonatal exposure to stress resemble symptoms of dysregulation associated with major depression. This study demonstrates that when applied concomitantly with the stressful challenge, the steroid GABA(A) receptor agonist 3,21-dihydropregnan-20-one (tetrahydrodeoxycorticosterone, THDOC) can attenuate the behavioral and neuroendocrine consequences of repeated maternal separation during early life, e.g., increased anxiety, an exaggerated adrenocortical secretory response to stress, impaired responsiveness to glucocorticoid feed-back, and altered transcription of the genes encoding corticotropin-releasing hormone (CRH) inthe hypothalamus and glucocorticoid receptors in the hippocampus. These data indicate that neuroactive steroid derivatives with GABA-agonistic properties may exert persisting stress-protective effects in the developing brain, and may form the basis for therapeutic agents which have the potential to prevent mental disorders resulting from adverse experience during neonatal life.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:15:36