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Titolo:
FTIR MICROSPECTROSCOPIC ANALYSIS OF HUMAN ILIAC CREST BIOPSIES FROM UNTREATED OSTEOPOROTIC BONE
Autore:
PASCHALIS EP; BETTS F; DICARLO E; MENDELSOHN R; BOSKEY AL;
Indirizzi:
HOSP SPECIAL SURG,535 E 70TH ST NEW YORK NY 10021 RUTGERS STATE UNIV,DEPT CHEM NEWARK NJ 07102
Titolo Testata:
Calcified tissue international
fascicolo: 6, volume: 61, anno: 1997,
pagine: 487 - 492
SICI:
0171-967X(1997)61:6<487:FMAOHI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSFORM INFRARED-SPECTROSCOPY; CALCIUM-PHOSPHATE; COMPONENTS; RESOLUTION; INVITRO; MATRIX;
Keywords:
OSTEOPOROSIS; BONE APATITE; FTIR MICROSPECTROSCOPY; OSTEON; CORTICAL BONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
E.P. Paschalis et al., "FTIR MICROSPECTROSCOPIC ANALYSIS OF HUMAN ILIAC CREST BIOPSIES FROM UNTREATED OSTEOPOROTIC BONE", Calcified tissue international, 61(6), 1997, pp. 487-492

Abstract

Historically, osteoporosis has been defined as a disease in which there is ''too little bone, but what there is, is normal. '' As a result of research design and sample selection limitations, published data contradict and confirm the historical definition. Because of these limitations, it has been hard to assess the contribution of mineral quality to mechanical properties, and to select therapeutic protocols that optimize bone mineral properties. The coupling of an optical microscope to an infrared spectrometer enables the acquisition of spectral data atknown sites in a histologic section of mineralized tissue without loss of topography and/or orientation. The use of second-derivative spectroscopy coupled with curve-fitting techniques allows the qualitative and quantitative assessment of mineral quality (crystallite size and perfection, mineral:matrix ratio) at well-defined morphologic locations. We have previously applied these techniques to the study of normal human osteonal, cortical, and trabecular bone. The results indicated that the newly deposited bone mineral is less ''crystalline/mature'' thanthe older one. In the present study, Fourier transform infrared microspectroscopy (FTIRM) was applied to the study of human osteonal and cortical bone from iliac crest biopsies of untreated osteoporotic patients. The hypothesis tested was that osteoporotic bone mineral is monotonically different in its properties expressed as ''crystallinity/maturity'' than the normal. The results indicate significant differences inthe mineral properties as expressed by crystal size and perfection, with the mineral from osteoporotic bone being more crystalline/mature than the normal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 06:40:04