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Titolo:
UNRAVELING THE ROLE OF STRUCTURE AND DENSITY IN DETERMINING VERTEBRALBONE STRENGTH
Autore:
VEENLAND JF; LINK TM; KONERMANN W; MEIER N; GRASHUIS JL; GELSEMA ES;
Indirizzi:
ERASMUS UNIV ROTTERDAM,DEPT MED INFORMAT,POSTBOX 1738 NL-3000 DR ROTTERDAM NETHERLANDS ERASMUS UNIV ROTTERDAM,DEPT RADIOL ROTTERDAM NETHERLANDS DEPT CLIN RADIOL MUNSTER GERMANY
Titolo Testata:
Calcified tissue international
fascicolo: 6, volume: 61, anno: 1997,
pagine: 474 - 479
SICI:
0171-967X(1997)61:6<474:UTROSA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE COMPUTED-TOMOGRAPHY; BODY COMPRESSIVE STRENGTH; TRABECULAR BONE; ASH DENSITY; RADIOGRAPHIC ANALYSIS; NORMAL INDIVIDUALS; FRACTAL SIGNATURE; LUMBAR VERTEBRAE; MINERAL DENSITY; ILIAC CREST;
Keywords:
VERTEBRAL STRENGTH; MAGNIFICATION RADIOGRAPHS; TEXTURE; QUANTITATIVE COMPUTED TOMOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
J.F. Veenland et al., "UNRAVELING THE ROLE OF STRUCTURE AND DENSITY IN DETERMINING VERTEBRALBONE STRENGTH", Calcified tissue international, 61(6), 1997, pp. 474-479

Abstract

The strength of bone is determined not only by bone density but also by structure. Therefore, quantification of the structure in radiographs by texture parameters may result in a better prediction of fracture risk. Since in radiographs density and structure are strongly correlated, the predictive power of texture parameters should be corrected forthe influence of BMD to determine the additional information conveyedby these parameters. in this study, we evaluated the predictive powerof various texture parameters based on the Grey-Level Dependence Method and the Morphological Gradient Method. This study was performed on 67 vertebrae obtained from 20 male and 12 female human cadaver thoracolumbar spines. BMD and area of the vertebral body were determined fromQCT images and texture parameters were derived from direct magnification (DIMA) radiographs. The fracture force, measured under conditions simulating the in vivo situation, was corrected with the area of the vertebra to yield the fracture stress (FS). Results of the study indicate that BMD correlates significantly with FS r = 0.82 (P < 0.001, n = 24) and r = 0.94 (P < 0.001, n = 43) for female and male vertebrae, respectively. Correlation coefficients of the investigated texture parameters were as high as 0.80 (P < 0.001) and 0.67 (P < 0.001) for the female and male vertebrae, respectively. Multiple regression analysis showed that in female vertebrae, the addition of one texture parameter to BMD results in a better prediction of strength. The multiple correlation coefficient was 0.87 (P < 0.001) in this case. in male vertebrae,BMD was the best predictor of fracture stress. These results suggest that texture parameters, as measured in magnification radiographs, canpredict bone strength. Whereas in ail cases BMD is the best single predictor of bone strength, for women texture parameters contain useful additional information.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:39:56