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Titolo:
INHIBITION OF VIRULENT MYCOBACTERIUM-TUBERCULOSIS BY BCG(R) AND BCG(S) MACROPHAGES CORRELATES WITH NITRIC-OXIDE PRODUCTION
Autore:
ARIAS M; ROJAS M; ZABALETA J; RODRIGUEZ JI; PARIS SC; BARRERA LF; GARCIA LF;
Indirizzi:
UNIV ANTIOQUIA,FAC MED,LAB CENT INVEST,AA 1226 MEDELLIN COLOMBIA UNIV ANTIOQUIA,FAC MED,LAB CENT INVEST MEDELLIN COLOMBIA
Titolo Testata:
The Journal of infectious diseases
fascicolo: 6, volume: 176, anno: 1997,
pagine: 1552 - 1558
SICI:
0022-1899(1997)176:6<1552:IOVMBB>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED MURINE MACROPHAGES; INTERFERON-GAMMA; L-ARGININE; NATURAL-RESISTANCE; INTRACELLULAR PARASITES; IFN-GAMMA; INFECTION; MICE; GENE; LEISHMANIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
M. Arias et al., "INHIBITION OF VIRULENT MYCOBACTERIUM-TUBERCULOSIS BY BCG(R) AND BCG(S) MACROPHAGES CORRELATES WITH NITRIC-OXIDE PRODUCTION", The Journal of infectious diseases, 176(6), 1997, pp. 1552-1558

Abstract

The Nramp1 gene controls macrophage resistance or susceptibility to several intracellular microorganisms; however, there is conflicting evidence regarding its role during infection with virulent Mycobacterium tuberculosis. Nitric oxide (NO) is a potent antimycobacterial agent produced by macrophages, which is also regulated by Nramp1. The in vitroability of B10R (resistant) and B10S (susceptible) murine macrophagesto inhibit M. tuberculosis H37Rv and to produce NO in response to infection and interferon-gamma (IFN-gamma) was compared. Infected B10R macrophages inhibited [H-3]uracil incorporation by ill, tuberculosis andproduced higher amounts of NO than did BIOS macrophages. IFN-gamma increased the inhibitory activity of both cells. Inhibition of M. tuberculosis by IFN-gamma-activated B10R macrophages was reversed by N-G-monomethyl-L-arginine (N(G)MMA). L-arginine restored NO production and increased the antimycobacterial activity by IFN-gamma-stimulated N(G)MMA-treated macrophages. The Bcg/Nramp1 gene may regulate macrophage resistance or susceptibility to virulent M. tuberculosis by a differentialcapability of these cells to produce NO.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 15:28:11