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Titolo:
AGE-RELATED-CHANGES OF THE MECHANICAL-PROPERTIES OF THE CAROTID-ARTERY IN SPONTANEOUSLY HYPERTENSIVE RATS
Autore:
ZANCHI A; BRUNNER HR; HAYOZ D;
Indirizzi:
CHU VAUDOIS,DIV HYPERTENS & VASC MED CH-1011 LAUSANNE SWITZERLAND CHU VAUDOIS,DIV HYPERTENS & VASC MED CH-1011 LAUSANNE SWITZERLAND
Titolo Testata:
Journal of hypertension
fascicolo: 12, volume: 15, anno: 1997,
pagine: 1415 - 1422
SICI:
0263-6352(1997)15:12<1415:AOTMOT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXIDE SYNTHASE INHIBITION; DISTENSIBILITY; HYPERTROPHY;
Keywords:
ARTERIAL DISTENSIBILITY; ULTRASONOGRAPHY; VASCULAR HYPERTROPHY; SPONTANEOUSLY HYPERTENSIVE RATS; STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
A. Zanchi et al., "AGE-RELATED-CHANGES OF THE MECHANICAL-PROPERTIES OF THE CAROTID-ARTERY IN SPONTANEOUSLY HYPERTENSIVE RATS", Journal of hypertension, 15(12), 1997, pp. 1415-1422

Abstract

Background We had previously demonstrated that the distensibility of the carotid artery in spontaneously hypertensive rats (SHR) aged 18 weeks does not differ from that of the carotid artery in normotensive animals for common pressure levels, despite vascular hypertrophy in SHR. Objective To examine the time-course effects of hypertension on the geometry and the mechanical properties of the carotid artery in SHR. Methods The mechanical behavior of the carotid arteries of anesthetized SHR, stroke-prone SHR (SHRSP), and Wistar-Kyoto (WKY) rats aged 4, 8, 12, 16, and 32 weeks was examined by simultaneously measuring the internal diameter with an A-mode ultrasonic echo-tracking device and the intra-arterial pressure with a computerized data-acquisition system. Histometric measurements of the carotid artery were performed after death of rats. Results Blood pressure increased with time in rats of the two genetic hypertensive models. However, it rose earlier and to higherlevels in the SHRSP. Cardiac hypertrophy was comparable in the two hypertensive groups whereas vascular hypertrophy was less pronounced in the SHRSP than it was in the SHR. There was an age-related decrease inarterial distensibility in rats of all groups that was more pronounced in the SHRSP than it was in the SHR compared with that in WKY rats (decreases of 57 and 36%, respectively, versus WKY rats aged 32 weeks; P < 0.05). For rats of all ages studied, although aging affected differently the vascular properties of the distinct animal strains, arterial distensibility was increased in the SHR and SHRSP compared with thatin control animals for similar blood pressure levels, implying a rightward shift of the distensibility-pressure curves in the two hypertensive models. However, there was a significant reduction in arterial distensibility in rats of the two hypertensive strains at their respective mean blood pressues, compared with that in control animals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 20:47:02