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Titolo:
THE ROLE OF REACTIVE OXYGEN AND NITROGEN SPECIES IN THE RESPONSE OF AIRWAY EPITHELIUM TO PARTICULATES
Autore:
MARTIN LD; KRUNKOSKY TM; DYE JA; FISCHER BM; JIANG NF; ROCHELLE LG; AKLEY NJ; DREHER KL; ADLER KB;
Indirizzi:
N CAROLINA STATE UNIV,COLL VET MED,DEPT ANAT PHYSIOL SCI & RADIOL,4700 HILLSBOROUGH ST RALEIGH NC 27606 N CAROLINA STATE UNIV,COLL VET MED,DEPT ANAT PHYSIOL SCI & RADIOL RALEIGH NC 27606 US EPA,NATL HLTH & ENVIRONM EFFECTS RES LAB RES TRIANGLE PK NC 27711
Titolo Testata:
Environmental health perspectives
, volume: 105, anno: 1997, supplemento:, 5
pagine: 1301 - 1307
SICI:
0091-6765(1997)105:<1301:TROROA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; INTERCELLULAR-ADHESION MOLECULE-1; OBSTRUCTIVE PULMONARY-DISEASE; NITRIC-OXIDE SYNTHASE; FACTOR-ALPHA; GENE-EXPRESSION; IN-VITRO; MINERAL DUSTS; ALVEOLAR MACROPHAGES; INHALED PARTICLES;
Keywords:
REACTIVE OXYGEN/NITROGEN SPECIES; SIGNAL TRANSDUCTION; AIRWAY INFLAMMATION; MUCIN HYPERSECRETION; ICAM-1; TNF-ALPHA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
78
Recensione:
Indirizzi per estratti:
Citazione:
L.D. Martin et al., "THE ROLE OF REACTIVE OXYGEN AND NITROGEN SPECIES IN THE RESPONSE OF AIRWAY EPITHELIUM TO PARTICULATES", Environmental health perspectives, 105, 1997, pp. 1301-1307

Abstract

Epidemiologic and occupational studies indicate adverse health effects due to inhalation of particulate air pollutants, but precise biologic mechanisms responsible have yet to be fully established. The tracheobronchial epithelium forms the body's first physiologic barrier to such airborne pollutants, where ciliary movement functions to remove the offending substances caught in the overlying mucus layer. Resident andinfiltrating phagocytic cells also function in this removal process. In this paper, we examine the role of reactive oxygen and nitrogen species (ROS/RNS) in the response of airway epithelium to particulates. Some particulates themselves can generate ROS, as can the epithelial cells, in response to appropriate stimulation. In addition, resident macrophages in the airways and the alveolar spaces carl release ROS/RNS after phagocytosis of inhaled particles. These macrophages also releaselarge amounts of tumor necrosis factor alpha (TNF-alpha), a cytokine that can generate responses within the airway epithelium dependent upon intracellular generation of ROS/RNS. As a result, signal transduction pathways are set in motion that may contribute to inflammation and other pathobiology in the airway. Such effects include increased expression of intercellular adhesion molecule 1, interleukin-6, cytosolic and inducible nitric oxide synthase, manganese superoxide dismutase, cytosolic phospholipase A(2), and hypersecretion of mucus. Ultimately, ROS/RNS may play a role in the global response of the airway epithelium to particulate pollutants via activation of kinases and transcription factors common to many response genes. Thus, defense mechanisms involved in responding to offending particulates may result in a complex cascade of events that can contribute to airway pathology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 08:43:05