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Titolo:
COEVOLUTION OF HUMAN-IMMUNODEFICIENCY-VIRUS AND CYTOTOXIC T-LYMPHOCYTE RESPONSES
Autore:
GOULDER P; PRICE D; NOWAK M; ROWLANDJONES S; PHILLIPS R; MCMICHAEL A;
Indirizzi:
UNIV OXFORD,JOHN RADCLIFFE HOSP,INST MOL MED,MOL IMMUNOL GRP OXFORD OX3 9DS ENGLAND UNIV OXFORD,JOHN RADCLIFFE HOSP,INST MOL MED,MOL IMMUNOL GRP OXFORD OX3 9DS ENGLAND UNIV OXFORD,JOHN RADCLIFFE HOSP,NUFFIELD DEPT CLIN MED OXFORD OX3 9DSENGLAND UNIV OXFORD,DEPT ZOOL OXFORD OX3 9DS ENGLAND
Titolo Testata:
Immunological reviews
, volume: 159, anno: 1997,
pagine: 17 - 29
SICI:
0105-2896(1997)159:<17:COHACT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESCAPE VIRAL VARIANTS; HIV-1 INFECTION; IN-VIVO; SEROPOSITIVE INDIVIDUALS; CHORIOMENINGITIS VIRUS; REVERSE-TRANSCRIPTASE; PERIPHERAL-BLOOD; FINE SPECIFICITY; IMMUNE-RESPONSE; NATURAL-HISTORY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
91
Recensione:
Indirizzi per estratti:
Citazione:
P. Goulder et al., "COEVOLUTION OF HUMAN-IMMUNODEFICIENCY-VIRUS AND CYTOTOXIC T-LYMPHOCYTE RESPONSES", Immunological reviews, 159, 1997, pp. 17-29

Abstract

After more than a decade of intensive research, the precise role of human immunodeficiency virus (HIV)-specific cytotoxic T lymphocytes (CTL) in determining the course of the infection remains open to argument. It is established that HIV-specific CTL appear early in the infection and are temporally associated with the clearance of culturable virusfrom the blood; that CLL are generally detectable at very high levelsthroughout the asymptomatic phase and decline at the time of progression to AIDS; and that CTL-mediated killing is sufficiently fast to prevent production of new virions by HIV-infected cells. However, viral turnover is high throughout the course of the infection, and infected individuals progress inexorably to disease in spite of the CTL response. In order to address the question of whether CTL play an active part in influencing the course of HIV infection, one approach has been to seek evidence for CTL-mediated selection pressure on the virus. Severalclear examples of CTL epitope-specific mutations selected to fixationare described. We argue that CTL escape is a common event which occurs at all stages of the infection. Detailed longitudinal studies are required to detect CTL escape and to understand the complexities contributed by factors such as a polyvalent CTL response and the presence of epitope variants which antagonise the CTL response. In conclusion, there is strong evidence of a dynamic process in which CTL impose important selection constraints upon HIV from which the virus attempts to escape; ultimately, at the time of disease progression, the tenuous control of CTL over the virus is lost.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 05:08:08