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Titolo:
THIOL LEVELS IN CD134-DEFINED SUBSETS OF RAT T-LYMPHOCYTES - POSSIBLEIMPLICATIONS FOR HGCL2-INDUCED IMMUNE DYSREGULATION
Autore:
ROOS A; CLAESSEN N; SCHILDERTOL EJM; CHAND MA; WEENING JJ; ATEN J;
Indirizzi:
UNIV AMSTERDAM,DEPT PATHOL,ACAD MED CTR,POB 22700 NL-1100 DE AMSTERDAM NETHERLANDS
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 2, volume: 240, anno: 1997,
pagine: 452 - 457
SICI:
0006-291X(1997)240:2<452:TLICSO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
BROWN NORWAY RAT; MERCURIC-CHLORIDE; INTRACELLULAR GLUTATHIONE; CELLULAR GLUTATHIONE; INDUCED AUTOIMMUNITY; CROSS-LINKING; OX40 LIGAND; LEWIS RATS; CELLS; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
A. Roos et al., "THIOL LEVELS IN CD134-DEFINED SUBSETS OF RAT T-LYMPHOCYTES - POSSIBLEIMPLICATIONS FOR HGCL2-INDUCED IMMUNE DYSREGULATION", Biochemical and biophysical research communications, 240(2), 1997, pp. 452-457

Abstract

CD134 (OX40), a member of the tumour necrosis factor receptor family,is expressed on activated T cells and mediates T and B cell costimulation. Its expression is increased after exposure to the thiol-binding compound HgCl2 in BN rats, but not in Lewis rats, in association with induction of a T cell-dependent systemic autoimmune syndrome only in BN rats. Intracellular thiols are involved in regulation of activation and death in T lymphocytes. Therefore, we examined intracellular thiollevels in CD134-defined T cell subsets from BN and Lewis rats. Levelsof total thiols and glutathione (GSH) were significantly higher in CD134(+)CD4(+) cells than in CD134(-)CD4(+) cells in both strains. In Lewis rats, total thiol levels in CD4(+)CD134(-) cells, but not in CD4(-)CD134(+) cells, were higher than in BN rats. In contrast, BN rats showed higher GSH levels in CD4(+)CD134(+) cells, but not in CD4(+)CD134(-) cells. In vitro exposure to HgCl2 decreased intracellular thiol levels, predominantly in CD4(+)CD134(-) cells. Furthermore, HgCl2-inducedenrichment of CD134(+) viable cells was inversely correlated to HgCl2-induced cell death. Strain-dependent differences in thiol levels in CD134-defined subsets of CD4(+) lymphocytes and subset-specific modification of thiol levels may contribute to differential lymphocyte activation by oxidizing chemicals. (C) 1997 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 20:52:07