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Titolo:
ASSOCIATION STUDY BETWEEN THE ANF GENE AND HYPERTENSION IN A GULF ARAB POPULATION
Autore:
FROSSARD PM; OBINECHE EN; LESTRINGANT GG; ELSHAHAT YI;
Indirizzi:
FAC MED & HLTH SCI,DEPT PATHOL,POB 17666 AL AIN U ARAB EMIRATES FAC MED & HLTH SCI,DEPT INTERNAL MED AL AIN U ARAB EMIRATES TAWAM HOSP,DEPT INTERNAL MED AL AIN U ARAB EMIRATES CENT HOSP,NEPHROL UNIT ABU ZABY U ARAB EMIRATES
Titolo Testata:
American journal of hypertension
fascicolo: 11, volume: 10, anno: 1997,
pagine: 1308 - 1310
SICI:
0895-7061(1997)10:11<1308:ASBTAG>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATRIAL-NATRIURETIC-PEPTIDE; BLOOD-PRESSURE; POLYMORPHISMS; LOCUS;
Keywords:
ASSOCIATION STUDY; ATRIAL NATRIURETIC FACTOR GENE; ESSENTIAL HYPERTENSION; I/D POLYMORPHISM; POLYMERASE CHAIN REACTION; UNITED ARAB EMIRATES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
P.M. Frossard et al., "ASSOCIATION STUDY BETWEEN THE ANF GENE AND HYPERTENSION IN A GULF ARAB POPULATION", American journal of hypertension, 10(11), 1997, pp. 1308-1310

Abstract

We have studied an insertion/deletion (I/D) dimorphism located in thesecond intron of the human atrial natriuretic factor (ANF) gene among232 United Arab Emirates (UAE) nationals (112 normotensives and 120 hypertensives) from the Abu Dhabi Emirate, with a view to evaluating the value of this marker in relation to hypertension. Our findings show that genotype frequencies of this I/D marker occur in Hardy-Weinberg proportions (respective genotype frequencies in the overall sample population are: II, 51%; ID, 42%; DD, 7%). No association, however, was evidenced between this dimorphic site and clinical diagnosis of essential hypertension. This suggests that: 1) this I/D dimorphism is not a useful marker to study the relationship between the ANF gene and hypertension in the UAE; and 2) variations of the ANF gene that may be in linkage disequilibrium with this marker do not play a major role in the determination of hypertension in this Arab population. (C) 1997 American Journal of Hypertension, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 13:57:47