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Titolo:
MYOCARDIAL WALL THICKNESS AND LEFT-VENTRICULAR GEOMETRY IN HYPERTENSIVES - RELATIONSHIP WITH INSULIN
Autore:
PAOLISSO G; GALDERISI M; TAGLIAMONTE MR; DEDIVITIS M; GALZERANO D; PETROCELLI A; GUALDIERO P; DEDIVITIS O; VARRICCHIO M;
Indirizzi:
UNIV NAPLES 2,DEPT GERIATR MED & METAB DIS,SERV ASTANTERIA MED,PIAZZAMIRAGLIA 2 I-80138 NAPLES ITALY UNIV NAPLES FEDERICO II,DEPT EMERGENCY MED NAPLES ITALY
Titolo Testata:
American journal of hypertension
fascicolo: 11, volume: 10, anno: 1997,
pagine: 1250 - 1256
SICI:
0895-7061(1997)10:11<1250:MWTALG>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; HYPERTROPHY; RESISTANCE; MASS; GROWTH; HYPERGLYCEMIA; METABOLISM; PROGNOSIS; MUSCLE; INVIVO;
Keywords:
ARTERIAL HYPERTENSION; ECHOCARDIOGRAPHIC PATTERNS; INSULIN ACTION; NONOXIDATIVE GLUCOSE METABOLISM; INSULIN RESISTANCE; LEFT VENTRICULAR HYPERTROPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
G. Paolisso et al., "MYOCARDIAL WALL THICKNESS AND LEFT-VENTRICULAR GEOMETRY IN HYPERTENSIVES - RELATIONSHIP WITH INSULIN", American journal of hypertension, 10(11), 1997, pp. 1250-1256

Abstract

In hypertensive patients the presence of left ventricular (LV) hypertrophy has been associated with a more severe degree of insulin resistance. Whether myocardial wall thickness or LV geometry are associated with a different degree of insulin resistance is still unknown in essential hypertensives. For this reason 26 men with new diagnosed essential hypertension were enrolled. All patients underwent echocardiographicexamination and euglycemic hyperinsulinemic glucose clamp combined with indirect calorimetry. According to LV mass and relative wall thickness data all patients were categorized in four groups: 1) patients with a normal geometric LV pattern (n = 8) (PAT = 0); 2) patients with concentric remodeling LV mass (n = 8) (PAT = 1);3) patients with eccentric LV hypertrophy (n = 3) (PAT = 2); and 4) patients with concentric LV hypertrophy (n = 7) (PAT = 3). All groups were similar for anthropometric characteristics. Patients with normal echocardiographic LV pattern (PAT = 0) had higher whole body glucose disposal (WBGD), oxidative and nonoxidative glucose metabolism, and lower lipid oxidation than patients with abnormal echocardiographic LV patterns (PAT = 1 to 3). Nevertheless, no significant differences among the groups with abnormal echocardiographic patterns were found. After controlling for age, body mass index (BMI), waist/hip ratio (WHR), and mean arterial blood pressure, only sum of the wall thickness was significantly correlated with fasting plasma insulin (r = -0.38, P < .05), WBGD (r = -0.50, P < .009), and NOGM (r = -0.48, P < .02). In multivariate analysis, a model made by age, BMI, WHR, systolic and diastolic blood pressure, and WBGD explained 38% of the echocardiographic pattern variability. In this model, WBGD (P < .02) was significantly and independently associated withechocardiographic patterns explaining 19% of the echocardiographic pattern variability. In conclusion, our data demonstrate that in arterial hypertension hyperinsulinemia/insulin resistance mainly affects myocardial wall thickness, whereas only a trivial association with LV geometry occurs. (C) 1997 American Journal of Hypertension, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 09:35:51