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Titolo:
MIXED OLIGOASTROCYTOMAS - A SURVIVAL AND PROGNOSTIC FACTOR-ANALYSIS
Autore:
SHAW EG; SCHEITHAUER BW; OFALLON JR; DAVIS DH;
Indirizzi:
MAYO CLIN & MAYO FDN,DIV RADIAT ONCOL,200 1ST ST SW ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,DEPT LAB MED & PATHOL ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,CANC STUDIES UNIT ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,DEPT NEUROL SURG ROCHESTER MN 55905
Titolo Testata:
Neurosurgery
fascicolo: 4, volume: 34, anno: 1994,
pagine: 577 - 582
SICI:
0148-396X(1994)34:4<577:MO-ASA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLIOMAS; ASTROCYTOMAS;
Keywords:
GRADING SYSTEMS; MIXED OLIGOASTROCYTOMA; OUTCOME; RADIATION THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
E.G. Shaw et al., "MIXED OLIGOASTROCYTOMAS - A SURVIVAL AND PROGNOSTIC FACTOR-ANALYSIS", Neurosurgery, 34(4), 1994, pp. 577-582

Abstract

SEVENTY-ONE PATIENTS WITH supratentorial mixed oligoastrocytomas underwent surgery only (5 patients) or surgery with postoperative radiation therapy (66 patients) between 1960 and 1982. The median survival forthese 71 patients was 5.8 years and the 5-, 10-, and 15-year survivalrates were 55, 29, and 17%, respectively-values significantly different from those of an age- and sex-matched normal reference population. Uni- and multivariate survival analyses were applied to 14 possible prognostic factors, including the following: patient factors-age, sex, and seizures; tumor factors-site, size, side, computed tomographic enhancement, and calcification; pathological factors-tumor grade and dominant cellular component; and treatment factors-extent of surgical resection, lobectomy, and radiation dose and field. Of these factors, tumorgrade, as determined by the Kernohan method, was the most strongly associated with survival. The 60 patients with Grades 1 and 2 tumors hada median survival of approximately 6.3 years and 5- and 10-year survival rates of 58% and 32%, respectively, compared with 2.8 years (36 and 9%, respectively) for the 11 patients with Grades 3 and 4 tumors. Age < 37 years, gross total resection, partial brain radiation, and radiation dose greater-than-or-equal-to 5000 cGy were other factors significantly associated with improved survival in both uni- and multivariate models. Three of five patients not receiving postoperative radiationtherapy experienced tumor recurrence and died. Seven of eight patients from whom tissue was obtained at the time of tumor progression demonstrated anaplastic transformation. In conclusion, this retrospective analysis suggests that maximum surgical resection plus postoperative radiation therapy, using partial brain treatment fields with doses greater-than-or-equal-to 5000 cGy, appears to be associated with improved survival for patients with mixed oligoastrocytomas.

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Documento generato il 27/11/20 alle ore 16:12:00