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Titolo:
RANDOMIZED TRIAL OF OCTREOTIDE FOR LONG-TERM MANAGEMENT OF CIRRHOSIS AFTER VARICEAL HEMORRHAGE
Autore:
JENKINS SA; BAXTER JN; CRITCHLEY M; KINGSNORTH AN; MAKIN CA; ELLENBOGEN S; GRIME JS; LOVE JG; SUTTON R;
Indirizzi:
ROYAL LIVERPOOL UNIV HOSP,CLIN & CANC TRIAL UNIT,DEPT SURG LIVERPOOL L7 8XP MERSEYSIDE ENGLAND ROYAL LIVERPOOL UNIV HOSP,CLIN & CANC TRIAL UNIT,DEPT SURG LIVERPOOL L7 8XP MERSEYSIDE ENGLAND ROYAL LIVERPOOL UNIV HOSP,DEPT NUCL MED LIVERPOOL L7 8XP MERSEYSIDE ENGLAND UNIV GLASGOW,ROBERTSON CTR BIOSTAT GLASGOW G12 8QQ LANARK SCOTLAND
Titolo Testata:
BMJ. British medical journal
fascicolo: 7119, volume: 315, anno: 1997,
pagine: 1338 - 1341
SICI:
0959-8138(1997)315:7119<1338:RTOOFL>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLEEDING ESOPHAGEAL-VARICES; PORTAL HYPERTENSIVE RATS; INJECTION SCLEROTHERAPY; SOMATOSTATIN ANALOG; REPERFUSION; SURVIVAL; LIGATION; PRESSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Jenkins et al., "RANDOMIZED TRIAL OF OCTREOTIDE FOR LONG-TERM MANAGEMENT OF CIRRHOSIS AFTER VARICEAL HEMORRHAGE", BMJ. British medical journal, 315(7119), 1997, pp. 1338-1341

Abstract

Objective: To assess the efficacy of long term octreotide as adjuvanttreatment to programmed endoscopic sclerotherapy after acute varicealhaemorrhage in cirrhotic portal hypertension. Design: Randomised clinical trial. Setting: University hospital. Subjects: 32 patients with cirrhotic portal hypertension. Interventions: Programmed injection sclerotherapy with subcutaneous octreotide 50 mu g twice daily for 6 months, or programmed injection sclerotherapy alone. Main outcome measures:Episodes of recurrent variceal bleeding and survival. Results: Significantly fewer patients receiving combined octreotide and sclerotherapyhad episodes of recurrent variceal bleeding compared with patients given sclerotherapy alone (1/16 v 7/16; P = 0.037, Fisher's exact test),and their survival was significantly improved (P < 0.02, log rank test); this improvement was maintained for 12 months after the end of thestudy. Combined treatment also resulted in a sustained decrease in portal pressure (median decrease -6.0 mm Hg, interquartile range -10 to -4.75 mm Hg, P = 0.0002) compared with sclerotherapy alone (median increase 1.5 mm Hg, interquartile range 0.25 to 3.25 mm Hg), as well as asignificant improvement in liver function as assessed by plasma concentrations of bilirubin, albumin, and alanine aminotransferase and by hepatocyte metabolism of aminopyrine labelled with carbon-14. Conclusion: Long term octreotide may be a valuable adjuvant to endoscopic sclerotherapy for acute variceal haemorrhage in cirrhotic portal hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:28:55