Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ANTISENSE OLIGONUCLEOTIDES AS THERAPEUTIC AGENTS
Autore:
ALAMA A; BARBIERI F; CAGNOLI M; SCHETTINI G;
Indirizzi:
IST NAZL RIC CANC,PHARMACOL LAB,DEPT PRECLIN ONCOL,LARGO R BENZI 10 I-16132 GENOA ITALY
Titolo Testata:
Pharmacological research
fascicolo: 3, volume: 36, anno: 1997,
pagine: 171 - 178
SICI:
1043-6618(1997)36:3<171:AOATA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE GEM-91; VIRUS GENE-EXPRESSION; IN-VIVO; CELL-PROLIFERATION; OLIGOMER COMPLEMENTARY; TISSUE DISTRIBUTION; IMMUNE STIMULATION; INHIBITS GROWTH; INFECTED-CELLS; MESSENGER-RNA;
Keywords:
ANTISENSE OLIGONUCLEOTIDES; GENE EXPRESSION; ONCOGENES; VIRAL TARGETS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
A. Alama et al., "ANTISENSE OLIGONUCLEOTIDES AS THERAPEUTIC AGENTS", Pharmacological research, 36(3), 1997, pp. 171-178

Abstract

The potential for modulating gene expression by the use of antisense oligonucleotides has become increasingly interesting in recent years. Antisense oligonucleotides are complementary nucleic acid fragments that hybridize to target sequences within RNA to form a DNA-RNA duplex, resulting in the block of translation of messenger RNA into the protein. Advances in chemistry and molecular biology have provided the basisto develop antisense oligodeoxynucleotides and improve their selectivity, stability and specificity of action. The antisense technology hasbeen extensively used in vitro and in vivo as a tool to study the regulatory mechanisms in biologic processes and as potential therapeutic agents in cancer, viral infections and genetic disorders. In the present review, the various approaches for the use of antisense molecules in oncology, virology, genetic and inflammatory diseases are described;several studies, supporting the in vitro and in vivo applications of this technology, are also presented. Moreover, the potential clinical use of antisense therapies is discussed. (C) 1997 The Italian Pharmacological Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 00:21:29