Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
STRUCTURE AND MECHANICS OF GROWING ARTERIAL MICROVESSELS FROM HYPERTROPHIED URINARY-BLADDER IN THE RAT
Autore:
BOELS PJ; ARNER A; MALMQVIST U; UVELIUS B;
Indirizzi:
LUND UNIV,DEPT PHYSIOL & BIOPHYS,SOLVEGATAN 19 S-22362 LUND SWEDEN LUND UNIV,DEPT PHYSIOL & BIOPHYS S-22362 LUND SWEDEN UNIV LUND HOSP,DEPT UROL S-22185 LUND SWEDEN
Titolo Testata:
Pflugers Archiv
fascicolo: 6, volume: 426, anno: 1994,
pagine: 506 - 515
SICI:
0031-6768(1994)426:6<506:SAMOGA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; INFRAVESICAL OUTFLOW OBSTRUCTION; MESENTERIC RESISTANCE VESSELS; SMOOTH-MUSCLE CELLS; CYTOSKELETAL PROTEINS; NORMOTENSIVE RATS; PORTAL-VEIN; BLOOD-FLOW; SENSITIVITY; NOREPINEPHRINE;
Keywords:
PHENYLEPHRINE; K+ SENSITIVITY; CA2+ SENSITIVITY; LENGTH/FORCE RELATION; SMOOTH MUSCLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
P.J. Boels et al., "STRUCTURE AND MECHANICS OF GROWING ARTERIAL MICROVESSELS FROM HYPERTROPHIED URINARY-BLADDER IN THE RAT", Pflugers Archiv, 426(6), 1994, pp. 506-515

Abstract

Rat bladder hypertrophy, induced by a partial ligation of the urethra, was used to study the accompanying changes of microvascular smooth muscle mechanics, pharmacology and morphology. A segment of a microarterial vessel to the bladder was taken from a defined anatomical location and studied in a wire myograph in vitro at the length for maximal isometric force development (L(max)). After 10 days of ligation, bladderhypertrophy resulted in a microvascular growth response compared to non-operated controls which was characterized by (i) an increase of thecalculated diameter at L(max) from 134 +/- 5 mu m to 222 +/- 19 mu m;(ii) an increase of the media thickness from 22.4 +/- 19 mu m to 32.2+/- 3.0 mu m; (iii) an increase of the active tension from 1.42 +/- 0.28 mN/mm to 3.06 +/- 0.33 mN/mm; (iv) no change of the wall/lumen ratio (from 0.83 +/- 0.10 to 0.79 +/- 0.15). Normalized length/force relations (active, passive and total) did not differ significantly betweenmicroarteries from control and hypertrophic bladders. Microvascular smooth muscle growth was also associated with a decreased sensitivity to K+-induced depolarization and an increased sensitivity to alpha(1)-adrenergic stimulation. No differences were noted regarding the Ca2+ sensitivity of force during K+-induced depolarization. The results suggest that microvascular growth (1) is immediately and positively influenced by the organ growth; (2) results in a functional resetting of the microvascular segments towards larger diameters without gross morphological or mechanical alterations; and (3) is accompanied by pharmacological alterations of the smooth muscle reactivity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 23:06:36