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Titolo:
EFFECTS OF SEROTONIN ON SYNAPTIC AND INTRINSIC-PROPERTIES OF RAT SUBICULAR NEURONS IN-VITRO
Autore:
BEHR J; EMPSON RM; SCHMITZ D; GLOVELI T; HEINEMANN U;
Indirizzi:
HUMBOLDT UNIV BERLIN,UNIV HOSP CHAR,INST PHYSIOL,DEPT NEUROPHYSIOL,TUCHOLSKYSTR 2 D-10117 BERLIN GERMANY HUMBOLDT UNIV BERLIN,UNIV HOSP CHAR,INST PHYSIOL,DEPT NEUROPHYSIOL D-10117 BERLIN GERMANY UNIV CALIF LOS ANGELES,SCH MED,REED NEUROL RES CTR,DEPT NEUROL LOS ANGELES CA 90095 UNIV CALIF LOS ANGELES,SCH MED,REED NEUROL RES CTR,DEPT PHYSIOL LOS ANGELES CA 90095 UNIV OXFORD,DEPT PHARMACOL OXFORD OX1 3QT ENGLAND
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 773, anno: 1997,
pagine: 217 - 222
SICI:
0006-8993(1997)773:1-2<217:EOSOSA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTEX IN-VITRO; PYRAMIDAL NEURONS; EPILEPTIFORM ACTIVITY; HIPPOCAMPAL REGION; DORSAL SUBICULUM; AREA CA1; RECEPTORS; BRAIN; SLICES; HETEROGENEITY;
Keywords:
SUBICULUM; INTRACELLULAR RECORDING; BURSTING CELL; REGULAR FIRING CELL; GABA(A); GABA(B); NMDA; AMPA; 5-HT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
J. Behr et al., "EFFECTS OF SEROTONIN ON SYNAPTIC AND INTRINSIC-PROPERTIES OF RAT SUBICULAR NEURONS IN-VITRO", Brain research, 773(1-2), 1997, pp. 217-222

Abstract

Intracellular recordings were performed to study the effects of 5-HT on membrane properties and EPSP/LPSP responses of subicular neurons inrat combined hippocampal-entorhinal cortex slices. Application of 5-HT induced in 76% of the investigated subicular cells a hyperpolarization and a reduction of membrane resistance. In bursting neurons, 5-HT caused a reduction of the depolarizing envelope underlying burst discharges and attenuated the subsequent afterhyperpolarization. While 5-HT decreased isolated AMPA/kainate and NMDA receptor-mediated responses as well as slow IPSPs, we could not find a consistent effect on isolated fast IPSPs. Since in approximate to 25% of subicular neurons EPSPs and slow IPSPs were reduced without any increase of membrane conductance, we conclude that 5-HT has in addition to membrane effects also effects on synaptic currents. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 03:23:33