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Titolo:
CHARACTERIZATION OF THE NOVEL FOCAL ADHESION KINASE RAFTK IN HEMATOPOIETIC-CELLS
Autore:
AVRAHAM S; AVRAHAM H;
Indirizzi:
HARVARD UNIV,INST MED,BIDMC,DIV EXPT MED,4 BLACKFAN CIRCLE BOSTON MA 02115 HARVARD UNIV,INST MED,BIDMC,DIV EXPT MED BOSTON MA 02115
Titolo Testata:
Leukemia & lymphoma
fascicolo: 3-4, volume: 27, anno: 1997,
pagine: 247 - 256
SICI:
1042-8194(1997)27:3-4<247:COTNFA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-TYROSINE KINASE; INTEGRIN-DEPENDENT PHOSPHORYLATION; SIGNAL-TRANSDUCTION; KAPOSIS-SARCOMA; GROWTH-FACTOR; INFLAMMATORY CYTOKINES; ACTIN CYTOSKELETON; TRANSFORMED-CELLS; MOLECULAR-CLONING; ACTIVATION;
Keywords:
NOVEL FOCAL ADHESION KINASE; RAFTK; HEMATOPOIETIC CELLS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
79
Recensione:
Indirizzi per estratti:
Citazione:
S. Avraham e H. Avraham, "CHARACTERIZATION OF THE NOVEL FOCAL ADHESION KINASE RAFTK IN HEMATOPOIETIC-CELLS", Leukemia & lymphoma, 27(3-4), 1997, pp. 247-256

Abstract

Protein tyrosine kinases (PTKs) mediate signals that respond to many pivotal cellular functions. Tyrosine phosphorylation, controlled by the coordinated actions of protein tyrosine phosphatases (PTPs) and PTKs, is a critical control mechanism for various physiological processes,including cell growth, differentiation, metabolism, cell cycle regulation and cytoskeleton function. The focal adhesion kinase (FAK) is a widely expressed non-receptor tyrosine kinase that is implicated in integrin-mediated signaling and plays a role in signal transduction pathways mediating cell adhesion, motility and anchorage-independent growth. Recently, we and others have identified a novel protein tyrosine kinase termed RAFTK, (also known as Pyk2 or Cak-beta), which is related to FAK. This review describes the role of RAFTK in various signaling cascades mainly in reference to hematopoietic cell lineages.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 18:02:17