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Titolo:
GENDER EFFECT OF THE TRP64ARG MUTATION IN THE BETA-3 ADRENERGIC-RECEPTOR GENE ON WEIGHT-GAIN IN MORBID-OBESITY
Autore:
CLEMENT K; MANNING BS; BASDEVANT A; STROSBERG AD; GUYGRAND B; FROGUEL P;
Indirizzi:
INST PASTEUR,CNRS,EP 10,1 RUE CALMETTE,BP 245 F-59019 LILLE FRANCE INST PASTEUR,CNRS,EP 10 F-59019 LILLE FRANCE LILLE UNIV HOSP LILLE FRANCE HOP HOTEL DIEU,DEPT NUTR F-75181 PARIS FRANCE INST COCHIN GENET MOL,LAB IMMUNOPHARMACOL MOL F-75014 PARIS FRANCE
Titolo Testata:
Diabetes & metabolism
fascicolo: 5, volume: 23, anno: 1997,
pagine: 424 - 427
SICI:
0338-1684(1997)23:5<424:GEOTTM>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN OB GENE; BETA(3)-ADRENERGIC-RECEPTOR GENE; INSULIN-RESISTANCE; EXTREME OBESITY; BETA(3)-ADRENOCEPTOR; POLYMORPHISM; VARIANT; FAT;
Keywords:
OBESITY; WEIGHT GAIN; BETA-3 ADRENERGIC RECEPTOR; MULTIFACTORIAL DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
K. Clement et al., "GENDER EFFECT OF THE TRP64ARG MUTATION IN THE BETA-3 ADRENERGIC-RECEPTOR GENE ON WEIGHT-GAIN IN MORBID-OBESITY", Diabetes & metabolism, 23(5), 1997, pp. 424-427

Abstract

Phenotypic expression of the Trp64Arg mutation in the beta 3-adrenoceptor gene (beta 3-AR) has been found to be somewhat variable among different populations, suggesting that it may be influenced by genetic background and environmental factors. As sex may also influence gene allellic expression, we evaluated a potential gender effect of the Trp64Arg mutation in 292 morbidly obese subjects [body mass index (BMI) greater than or equal to 40 m/kg(2)]. Although the 15 mutated obese females were younger than the non-mutated ones, the difference between theircurrent weight and their weight at 20 years was significantly higher (62.4 +/- 20.0 kg versus 47.0 +/- 24.0 kg; p = 0.017). Moreover in themutated heterozygous female group, the mean Zscore (individual BMI minus reference French population mean BMI/SD of reference population BMI) was significantly higher (8.0 +/- 2.5 versus 6.0 +/- 2.0 SD of BMI,p = 0.0018), as was the maximal Zscore calculated from the maximal BMI that obese females reached during life (9.0 +/- 3.0 versus 7.0 +/- 2.5, p = 0.005). The regression curves of the Zscore against age showedthat the curve of mutated females was shifted to the top, indicating that their BMI was higher regardless of age. These effects were not observed in the male group (the Zscore was 6.7 +/- 3.0 vs. 7.2, p = 0.7 respectively in mutated and non-mutated men). These data reinforce thehypothesis that the expression of the beta 3-AR susceptibility gene depends on additional factors including gender and possibly hormonal status.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 19:41:11